Dokument: Rational development of orodispersible minitablets under particular consideration of the lubrication system
| Titel: | Rational development of orodispersible minitablets under particular consideration of the lubrication system |
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73577 |
| URN (NBN): | urn:nbn:de:hbz:061-20260623-153235-2 |
| Kollektion: | Dissertationen |
| Sprache: | Englisch |
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation |
| Medientyp: | Text |
| Autor: | Kuck, Jennifer [Autor] |
| Dateien: | Die Dateien dieses Dateibereiches sind derzeit nicht frei zugänglich. Klicken Sie hier, um sich mit zusätzlichen Rechten beim Dokumentenserver anzumelden! |
| Beitragende: | Prof. Dr. Breitkreutz, Jörg [Gutachter] Jun.-Prof. Dr. Hacker, Michael [Gutachter] |
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit |
| Beschreibung: | Orodispersible minitablets (ODMTs) are a suitable dosage form for the pediatric population or patients with swallowing difficulties. This was underlined by the recent market approval of Aqumeldi®, the first single-dosed, orodispersible minitablet. As the specific challenges in manufacturing and development of ODMTs, particularly regarding the lubrication impact, have not been thouroughly investigated., this thesis adresses this research gap.
Two of the commonly used lubricants were compared for two different tablet sizes in combination with one of five commercially available co-processed excipients. Moreover, the external lubrication with MgSt was studied specifically for minitablets. As multi-tip dies are used in the industrial production of minitablets, several dies and tips have to be covered during atomization of the lubricant and were studied separately for different positions of the multi-tip die. In addition, two excipients, containing an integrated lubricant, were evaluated regarding their suitability for ODMTs. Subsequently, the effect of the lubrication system was studied for ODMT formulationst with a water soluble and a poorly soluble model API. Finally, the suitability of a digital formulation assistant for the development of ODMTs was studied. |
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz |
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Pharmazie » Pharmazeutische Technologie und Biopharmazie |
| Dokument erstellt am: | 23.06.2026 |
| Dateien geändert am: | 23.06.2026 |
| Promotionsantrag am: | 03.12.2025 |
| Datum der Promotion: | 23.04.2026 |
