Dokument: Learning Different Types of Associations with Immediate and Delayed Feedback: Neural Mechanisms and Clinical Perspectives
| Titel: | Learning Different Types of Associations with Immediate and Delayed Feedback: Neural Mechanisms and Clinical Perspectives | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=70760 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250917-130935-7 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Röhlinger, Madita [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Bellebaum, Christian [Gutachter] Prof. Dr. Becker, Susanne [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 100 Philosophie und Psychologie » 150 Psychologie | |||||||
| Beschreibung: | Midbrain dopamine neurons encode whether feedback is better or worse than expected, sending this reinforcement learning signal to striatal and fronto-cortical regions to provide a neural basis for learning and adaptive behavior. When feedback is temporally delayed, processing appears to shift from the striatum to regions within the medial temporal lobe (MTL). This dissertation set out to shed light on the question of how the brain links feedback to specific events despite temporal gaps between them, and whether the underlying mechanisms are altered in depression. In three consecutive studies using electroencephalography, it was explored how feedback timing, different association types, and depression influence two event related potential components—namely, the feedback-related negativity (FRN) and N170—which have been associated with feedback processing in the striatum and MTL, respectively. Across all studies, both components scaled with feedback that was better or worse than expected, interestingly reflecting the full range of prediction errors. Contrary to previous views of a mutual inhibition between striatum and MTL during feedback learning, results from Study 1 suggest that various brain regions giving rise to the FRN and N170 receive the same reinforcement learning signal and work together to support immediate and delayed feedback processing, as well as the formation of various types of associations. Study 2 further demonstrated that the N170 was especially pronounced when visual stimuli were linked to delayed feedback. This suggests that, in addition to MTL activity, the N170 may also be driven by reactivations of visual areas, providing a mechanism for linking feedback to previous events. Adding to earlier findings of an altered FRN in depression, Study 3 indicates that the N170 may serve as an additional biomarker in future clinical research. To conclude, this dissertation provides insights into fundamental mechanisms of learning and their disruption in the context of mental disorders. | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Psychologie » Experimentelle Biologische Psychologie | |||||||
| Dokument erstellt am: | 17.09.2025 | |||||||
| Dateien geändert am: | 17.09.2025 | |||||||
| Promotionsantrag am: | 01.07.2025 | |||||||
| Datum der Promotion: | 04.09.2025 |
