Dokument: Reconstructing rearrangement phylogenies of natural genomes
| Titel: | Reconstructing rearrangement phylogenies of natural genomes | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=70044 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250630-132631-2 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Bohnenkämper, Leonard [Autor] Stoye, Jens [Autor] Doerr, Daniel [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Integer linear programming, Ancestral reconstruction, Doublecut- and-join, Genome rearrangement, Small parsimony | |||||||
| Beschreibung: | Background
We study the classical problem of inferring ancestral genomes from a set of extant genomes under a given phylogeny, known as the Small Parsimony Problem (SPP). Genomes are represented as sequences of oriented markers, organized in one or more linear or circular chromosomes. Any marker may appear in several copies, without restriction on orientation or genomic location, known as the natural genomes model. Evolutionary events along the branches of the phylogeny encompass large scale rearrangements, including segmental inversions, translocations, gain and loss (DCJ-indel model). Even under simpler rearrangement models, such as the classical breakpoint model without duplicates, the SPP is computationally intractable. Nevertheless, the SPP for natural genomes under the DCJ-indel model has been studied recently, with limited success. Methods Building on prior work, we present a highly optimized ILP that is able to solve the SPP for sufficiently small phylogenies and gene families. A notable improvement w.r.t. the previous result is an optimized way of handling both circular and linear chromosomes. This is especially relevant to the SPP, since the chromosomal structure of ancestral genomes is unknown and the solution space for this chromosomal structure is typically large. Results We benchmark our method on simulated and real data. On simulated phylogenies we observe a considerable performance improvement on problems that include linear chromosomes. And even when the ground truth contains only one circular chromosome per genome, our method outperforms its predecessor due to its optimized handling of the solution space. The practical advantage becomes also visible in an analysis of seven Anopheles taxa. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Bohnenkämper, L., Stoye, J., & Dörr, D. (2025). Reconstructing rearrangement phylogenies of natural genomes. Algorithms for Molecular Biology, 20, Article 10. https://doi.org/10.1186/s13015-025-00279-5 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 30.06.2025 | |||||||
| Dateien geändert am: | 30.06.2025 |
