Dokument: Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma
| Titel: | Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68816 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250226-102140-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Picard, Daniel [Autor] Felsberg, Jörg [Autor] Langini, Maike [Autor] Stachura, Pawel [Autor] Qin, Nan [Autor] Macas, Jadranka [Autor] Reiss, Yvonne [Autor] Bartl, Jasmin [Autor] Selt, Florian [Autor] Sigaud, Romain [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Intertumoral heterogeneity, Integrative multi-omics, Pilocytic astrocytoma | |||||||
| Beschreibung: | Pilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or activating mutations. While 5-year overall survival rates exceed 95%, tumor recurrence or progression constitutes a major clinical challenge in incompletely resected tumors. Here, we used similarity network fusion (SNF) analysis in an integrative multi-omics approach employing RNA transcriptomic and mass spectrometry-based proteomic profiling to molecularly characterize PA tissue samples from 62 patients. Thereby, we uncovered that PAs segregated into two molecularly distinct groups, namely, Group 1 and Group 2, which were validated in three non-overlapping cohorts. Patients with Group 1 tumors were significantly younger and showed worse progression-free survival compared to patients with group 2 tumors. Ingenuity pathways analysis (IPA) and gene set enrichment analysis (GSEA) revealed that Group 1 tumors were enriched for immune response pathways, such as interferon signaling, while Group 2 tumors showed enrichment for action potential and neurotransmitter signaling pathways. Analysis of immune cell-related gene signatures showed an enrichment of infiltrating T Cells in Group 1 versus Group 2 tumors. Taken together, integrative multi-omics of PA identified biologically distinct and prognostically relevant tumor groups that may improve risk stratification of this single pathway driven tumor type. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Picard, D., Felsberg, J., Langini, M., Stachura, P., Qin, N., Macas, J., Reiss, Y., Bartl, J., Selt, F., Sigaud, R., Meyer, F.-D., Stefanski, A., Stühler, K., Roque, L., Roque, R., Pandyra, A. A., Brozou, T., Knobbe-Thomsen, C. B., Plate, K. H., … Remke, M. (2023). Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma. Acta Neuropathologica, 146(4), 551–564. https://doi.org/10.1007/s00401-023-02626-5 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 26.02.2025 | |||||||
| Dateien geändert am: | 26.02.2025 |
