Dokument: Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus
| Titel: | Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67826 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241202-123505-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Zaharia, Oana-Patricia [Autor] Strassburger, Klaus [Autor] Knebel, Birgit [Autor] Binsch, Christian [Autor] Kupriyanova, Yuliya [Autor] Möser, Clara [Autor] Bódis, Kálmán Benedikt [Autor] Prystupa, Katsiaryna [Autor] Yurchenko, Iryna [Autor] Mendez Cardenas, Dania Marel [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Genetic variant, Nephropathy, Steatosis | |||||||
| Beschreibung: | Aims
We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (PNPLA3) gene, with chronic kidney disease in diabetes endotypes. Methods Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL). Results Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p < 0.05). HCL was negatively associated with eGFR (r = −0.287, p < 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR >60 ml/min to 52 % for eGFR <60 ml/min (p < 0.05). Conclusions The PNPLA3 polymorphism may contribute to declining kidney function independently of liver lipids. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Zaharia, O. P., Strassburger, K., Knebel, B., Binsch, C., Kupriyanova, Y., Möser, C., Bódis, K., Prystupa, K., Yurchenko, I., Mendez Cardenas, D. M., Schön, M., Herder, C., Al-Hasani, H., Schrauwen-Hinderling, V., Jandeleit-Dahm, K., Wagner, R., & Roden, M. (2024). Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus. Diabetes & Metabolic Syndrome, 18(10), Article 103137. https://doi.org/10.1016/j.dsx.2024.103137 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 02.12.2024 | |||||||
| Dateien geändert am: | 02.12.2024 |
