Dokument: Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking
| Titel: | Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73930 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260713-140311-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Vinnenberg, Laura [Autor] Jan Ravoo, Bart [Autor] Gatsogiannis, Christos [Autor] Budde, Thomas [Autor] Meuth, Sven G [Autor] | |||||||
| Dateien: |
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| Beschreibung: | Ion channels are classically regarded as regulators of electrical excitability, but their role in immune activation and barrier homeostasis extends far beyond global transmembrane ion flux. This functional diversity is, among other things, the result of noncanonical signaling pathways. In this review, we examine the neurovascular endothelium as a paradigm for barrier-associated neuroimmune pathology and discuss three mechanistic principles: (1) permeation-independent scaffolding via cytoplasmic interaction domains, (2) spatio-temporally restricted ion flux within signaling microdomains, and (3) compartmentalized or cargo-mediated signaling. These mechanisms shape endothelial barrier integrity, inflammatory junctional remodeling, and the diapedesis of immune cells across the blood-brain barrier. A deeper understanding of such noncanonical channel functions opens new therapeutic perspectives beyond conventional pore blockade, including the targeted modulation of signaling domains, protein interactions, and subcellular channel localization. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Vinnenberg, L., Jan Ravoo, B., Gatsogiannis, C., Budde, T., & Meuth, S. G. (2026). Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking. Current opinion in immunology, 101, Article 102813. https://doi.org/10.1016/j.coi.2026.102813 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 13.07.2026 | |||||||
| Dateien geändert am: | 13.07.2026 |
