Dokument: Determinants of Entero-Invasive and Non-Entero-Invasive Diarrheagenic Bacteria Among HIV-Positive and HIV-Negative Adults in Ghana
| Titel: | Determinants of Entero-Invasive and Non-Entero-Invasive Diarrheagenic Bacteria Among HIV-Positive and HIV-Negative Adults in Ghana | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73611 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260615-130545-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Tufa, Tafese Beyene [Autor] Luedde, Tom [Autor] Feldt, Torsten [Autor] Eberhardt, Kirsten Alexandra [Autor] Frickmann, Hagen [Autor] Sarfo, Fred Stephen [Autor] Norman, Betty Roberta [Autor] Dompreh, Albert [Autor] Asibey, Shadrack Osei [Autor] Boateng, Richard [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | Salmonella , Campylobacter , Arcobacter butzleri , enterotoxigenic , Shigella , immunosuppression , enteroaggregative , Escherichia coli , HIV , enteropathogenic | |||||||
| Beschreibung: | Objectives: This observational and cross-sectional study investigated differential associations between entero-invasive and non-entero-invasive enteric pathogens and HIV infection, considering socioeconomic, clinical and immunological aspects. In a Ghanaian population with a high prevalence of enteric pathogens, stool samples from people living with HIV (PLWH) were screened for Salmonella spp., Shigella spp./EIEC (enteroinvasive Escherichia coli), and Campylobacter jejuni as entero-invasive bacteria, for enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), and enteroaggregative E. coli (EAEC) as non-entero-invasive bacteria. Arcobacter butzleri, with uncertain enteropathogenicity, was also included. Methods: Stool samples from PLWH (with and without antiretroviral therapy) and HIV-negative controls were analyzed by real-time PCR for the presence and quantity of the selected enteropathogens. Results were correlated with socioeconomic, clinical, and immunological parameters. Results: The presence of Shigella spp. /EIEC in stool was both qualitatively and quantitatively associated with reduced CD4+ T lymphocyte counts and was qualitatively associated with clinically apparent diarrhea. EAEC showed a weak positive association with HIV infection, supported by a negative correlation between EAEC DNA quantity and CD4+ T lymphocyte counts. EPEC colonization was associated with HIV negativity, higher CD4+ T lymphocyte counts, and lower socioeconomic status. Abundance of Salmonella enterica was associated with clinically apparent diarrhea. Conclusions: This explorative, hypothesis-forming study suggests species- or pathovar-specific associations between enteric bacterial pathogens and HIV-related immunosuppression. Observed relationships with clinically apparent diarrhea largely align with findings from sub-Saharan African children, except for a more pronounced association between diarrhea and Salmonella in this cohort. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Frickmann, H., Sarfo, F. S., Norman, B. R., Dompreh, A., Asibey, S. O., Boateng, R., Di Cristanziano, V., Tufa, T. B., Loderstädt, U., Binder, R., Zautner, A. E., Lüdde, T., Feldt, T., & Eberhardt, K. A. (2025). Determinants of Entero-Invasive and Non-Entero-Invasive Diarrheagenic Bacteria Among HIV-Positive and HIV-Negative Adults in Ghana. Medical Sciences, 13(4), Article 316. https://doi.org/10.3390/medsci13040316 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 15.06.2026 | |||||||
| Dateien geändert am: | 15.06.2026 |
