Dokument: Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs
| Titel: | Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73434 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260529-111039-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Thiel, Thomas A. [Autor] Wittsack, Hans-Jörg [Autor] Ljimani, Alexandra [Autor] Stabinska, Julia [Autor] Zöllner, Helge J. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | IVIM , intravoxel incoherent motion , perfusion fraction , liver , T2-IVIM | |||||||
| Beschreibung: | Purpose: To quantitatively assess the bias in the intravoxel incoherent motions (IVIM)–derived pseudo-diffusion volume fraction (f) caused by the differences in relaxation times between the tissue and fluid compartments, and to develop a two-dimensional (b-value-TE) fitting approach for simultaneous T2 and IVIM parameter estimation along with an optimal acquisition protocol for the relaxation-compensated T2-IVIM imaging in the liver.
Methods: Simulations were conducted to investigate the TR- and TE-dependent bias in f when using the IVIM model, and to evaluate the applicability of the 2D T2-IVIM model for reducing this bias. The numerical findings were then validated using the in vivo IVIM data from four healthy volunteers on a 3-Tesla MRI scanner. Finally, a numerical framework for optimizing the T2-IVIM protocol for relaxation-compensated f parameter estimation was proposed and tested using the in vivo data. Results: In vivo, the traditional IVIM model showed a trend toward higher f with increasing TE in the liver (R = 0.46, p = 0.023), but not in the kidney cortex (R = −0.067, p = 0.76) or medulla (R = 0.039, p = 0.86). In both simulations and in vivo, 2D T2-IVIM modeling yielded lower f values and reduced variability in the liver. Our results further suggest that a b-TE protocol with six b-values and three TEs (50, 60, and 100 ms) may be optimal for liver T2-IVIM. Conclusion: The extended 2D T2-IVIM model effectively minimizes the TE dependent bias in f and allows simultaneous estimation of the IVIM parameter and compartmental T2 values in abdominal organs. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Stabinska, J., Thiel, T., Wittsack, H.-J., Ljimani, A., & Zöllner, H. J. (2026). Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs. Magnetic Resonance in Medicine, 95(6), 3161–3175. https://doi.org/10.1002/mrm.70278 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 29.05.2026 | |||||||
| Dateien geändert am: | 29.05.2026 |
