Dokument: Effect of Additively Manufactured Sphene Ceramic Scaffolds on Bone Response in Rat Critical-Size Calvarial Defects
| Titel: | Effect of Additively Manufactured Sphene Ceramic Scaffolds on Bone Response in Rat Critical-Size Calvarial Defects | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73375 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260526-121719-8 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Brunello, Giulia [Autor] Elsayed, Hamada [Autor] Schiavon, Lucia [Autor] Sbettega, Elia [Autor] Iezzi, Giovanna [Autor] Zavan, Barbara [Autor] Carmignato, Simone [Autor] Bernardo, Enrico [Autor] Biasetto, Lisa [Autor] Sivolella, Stefano [Autor] | |||||||
| Dateien: |
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| Stichwörter: | bioactive ceramic , direct ink writing , scaffold , bone regeneration , sphene | |||||||
| Beschreibung: | Silica-based bioceramics are promising bone substitutes with tunable degradation and mechanical properties. We aimed to assess bone response in critical-size calvarial defects in rats, empty or filled with 3D-printed sphene ceramic (CaTiSiO5) scaffolds produced using direct ink writing from preceramic polymers and reactive fillers. Scaffold characterization was performed using scanning electron microscopy, X-ray diffraction, porosity analysis, and compressive strength testing. Bilateral cylindrical 5 mm calvarial defects were created in 20 rats: one was randomly filled with sphene scaffold, while the contralateral remained empty. Ten animals were killed at 4 weeks, the rest at 8 weeks. Specimens were collected for micro-X-ray computed tomography (micro-CT) analysis, followed by undecalcified histology. The scaffolds exhibited porous structure with complete sphene phase purity and compressive strength of 17.91 MPa (SD 4.6). In vivo, no adverse event was noted during healing. Overall bone regeneration—as measured by BV/TV—was comparable between groups: Bone volume/total volume (BV/TV) increased over time in the empty and sphene groups, reaching ~40%, with no significant differences between groups or time points. BV/TV was significantly higher in the external regions of the defects compared to the internal areas in both groups at the two time points. The sphene group showed a significantly greater volume of new bone extending beyond the original cortical boundary at both 4 and 8 weeks (p = 0.013). In the sphene group histology revealed partial bone ingrowth within the scaffold, while bone in the control group was limited to defect edges. After 8 weeks, new bone adjacent to the cortical surface was thicker in the sphene group (p < 0.05). These initial findings are consistent with prior preclinical studies, supporting the biocompatibility and osteoconductive nature of sphene ceramic scaffolds. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Brunello, G., Elsayed, H., Schiavon, L., Sbettega, E., Iezzi, G., Zavan, B., Carmignato, S., Bernardo, E., Biasetto, L., & Sivolella, S. (2026). Effect of Additively Manufactured Sphene Ceramic Scaffolds on Bone Response in Rat Critical-Size Calvarial Defects. Applied Sciences, 16(7), Article 3121. https://doi.org/10.3390/app16073121 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 26.05.2026 | |||||||
| Dateien geändert am: | 26.05.2026 |
