Dokument: Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study
| Titel: | Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73168 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260504-142328-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Gallinnis, Patrik Jan [Autor] Kamp, Benedikt [Autor] Radke, Karl Ludger [Autor] Möller, Rika [Autor] Juric, Anna-Katharina [Autor] Antoch, Gerald [Autor] Wittsack, Hans-Jörg [Autor] Ljimani, Alexandra [Autor] Müller-Lutz, Anja [Autor] Stabinska, Julia [Autor] | |||||||
| Dateien: |
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| Stichwörter: | amide proton transfer , abdominal CEST , chemical exchange saturation transfer , magnetization transfer imaging , dynamic phantom , kidney | |||||||
| Beschreibung: | Purpose:
The aim is to evaluate the effectiveness of timed breathing in reducing respiratory motion artifacts in renal chemical exchange saturation transfer (CEST) MRI and to assess potential differences in CEST effects between renal compartments. Methods: An electro-pneumatic phantom with a kidney CEST model simulated variable respiratory motion and sequence-synchronized breathing. Motion-induced deviations from a static reference were quantified using the mean absolute error (MAE). Ten healthy volunteers (six females, four males; 25.2 ± 1.9 years) and one patient (47 years) with ccRCC (3.0 × 2.2 × 2.2) cm3 were examined on a 3 T MRI system using a multi-echo gradient echo sequence with 15 Gaussian-shaped saturation pulses (B1 = 1.5 μT, tp = tipd = 100 ms). CEST effects in cortex, medulla, and pelvis at 1.0, 2.0, and 3.5 ppm were quantified by MTR asym analysis under timed and free-breathing conditions. Results: Timed breathing reduced motion artifacts in both phantom and in vivo data. MTR asym analysis exhibits visibly distinguishable and significantly different (p < 0.05) CEST effects in renal compartments, with increased MTRasym values of (0.78% ± 0.41%) at 1.0 ppm in the cortex, (1.43% ± 0.70%) at 2.0 ppm in the medulla, and (−2.02% ± 0.84%) at 3.5 ppm in the pelvis. Significant differences (p < 0.05) in MTRasym values were observed between the patient and the healthy cohort. Conclusion: Timed breathing improves renal CEST MRI by reducing motion artifacts and enabling detection of compartment-specific CEST effects, highlighting its potential for biochemical characterization of renal tissue in clinical applications. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung :
Gallinnis, P., Kamp, B., Radke, K. L., Möller, R., Juric, A.-K., Stabinska, J., Herynek, V., Antoch, G., Wittsack, H.-J., Ljimani, A., & Müller-Lutz, A. (2025). Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study. Magnetic Resonance in Medicine, 95(4), 2194–2206. https://doi.org/10.1002/mrm.70210 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 04.05.2026 | |||||||
| Dateien geändert am: | 04.05.2026 |
