Dokument: Theranostic Toolbox for Neutrophil Functionalization
| Titel: | Theranostic Toolbox for Neutrophil Functionalization | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=73112 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260429-135208-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Bouvain, Pascal [Autor] Thomy, Kay-Matthias [Autor] Prinz, Anika Maria [Autor] Steckel, Bodo [Autor] Kadir, Shiwa [Autor] Röhs, Alexandra [Autor] Schmitz, Jonas [Autor] Dohle, Claudia [Autor] Karg, Matthias [Autor] Grandoch, Maria [Autor] | |||||||
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| Stichwörter: | neutrophils , fluorine , inflammation , thera- nostics , targeted nanoparticles , MRI | |||||||
| Beschreibung: | Neutrophils are crucial for fighting invading pathogens and for the clearance of sterile wounds. However, in cases of overwhelming pathogens or excessive inflammatory responses, fine-tuning of neutrophil functions can help to either enhance bacterial killing or prevent unwanted tissue damage. Thus, the present study is aimed at developing a nanoparticle-based toolbox to direct neutrophils toward either a proinflammatory or reparative phenotype tailored
to the specific inflammatory environment. For this, neutrophil-specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background-free 19 F MRI-based theranostic approach are engineered. It is demonstrated that with this i) distinct effector functions can be specifically modulated in both murine and human neutrophils, ii) the disease-specific degree of neutrophil infiltration can be non-invasively monitored in vivo, and in turn iii) neutrophil effector functions can either be attenuated during a pharmacological challenge or amplified to ameliorate tissue damage during bacteria-driven acute colitis. Thus, this nanotheranostic approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to improve disease course and outcome, thus paving the way for a personalized neutrophil immunotherapy. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Bouvain, P., Thomy, K.-M., Prinz, A. M., Steckel, B., Kadir, S., Röhs, A., Schmitz, J., Dohle, C., Karg, M., Grandoch, M., Flögel, U., & Temme, S. (2025). Theranostic Toolbox for Neutrophil Functionalization. Advanced Science, 12(34), Article e04412. https://doi.org/10.1002/advs.202504412 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 29.04.2026 | |||||||
| Dateien geändert am: | 29.04.2026 |
