Dokument: First Direct Evidence of Accelerated Molecular Aging in Intracranial Aneurysmal Tissue
| Titel: | First Direct Evidence of Accelerated Molecular Aging in Intracranial Aneurysmal Tissue | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72832 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260402-133843-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Khan, Dilaware [Autor] Li, Xuanchen [Autor] Hewera, Michael [Autor] Muhammad, Sajjad [Autor] | |||||||
| Dateien: |
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| Stichwörter: | mTOR , telomere length , NF- κB , oxidative stress-induced DNA damage , molecular aging | |||||||
| Beschreibung: | The risk for cardiovascular diseases increases with age. Various markers for vascular aging have been suggested. However, these markers are not a direct measure of aging in vessels. Telomere length quantification can directly measure vascular aging—the current study aimed to investigate aging in aneurysm tissue by quantifying telomere length. Non-diseased control vessels and ruptured and unruptured intracranial aneurysm vessels were resected during surgery. Telomere length quantification revealed a shorter telomere length in intracranial aneurysm tissue than in the non-diseased control vessel. The difference in telomere length between non-diseased control vessels and intracranial aneurysm tissue remained significant after normalizing for age. Moreover, the intracranial aneurysm tissue showed a lower expression of the aging marker Lamin B1 and a higher expression of the senescence marker P21. Additionally, intracranial aneurysm tissue presented higher activation of mTOR and NF-κB pathways, which are known to contribute to inflammation and aging. Oxidative stress-induced DNA damage appeared higher in intracranial aneurysm tissue than in non-diseased control vessels. Our human data clearly showed increased molecular aging, elevated oxidative stress, and the activation of aging and inflammation-associated pathways NF-κB and mTOR in intracranial aneurysm tissue compared to non-diseased control vessels. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Khan, D., Li, X., Hewera, M., & Muhammad, S. (2025). First Direct Evidence of Accelerated Molecular Aging in Intracranial Aneurysmal Tissue. Aging Cell, 24(11), Article e70231. https://doi.org/10.1111/acel.70231 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 02.04.2026 | |||||||
| Dateien geändert am: | 02.04.2026 |
