Dokument: Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes
| Titel: | Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72792 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260401-114132-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Kupriyanova, Yuliya [Autor] Yurchenko, Iryna [Autor] Bobrov, Pavel [Autor] Bartels, Frederik [Autor] Wierichs, Stefan [Autor] Jonuscheit, Marc [Autor] Korzekwa, Benedict [Autor] Prystupa, Katsiaryna [Autor] Schön, Martin [Autor] Mendez, Dania [Autor] | |||||||
| Dateien: |
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| Beschreibung: | Introduction
The study aimed to assess the effect of COVID-19 on hepatic lipid (HL) content, fibrosis risk, and adiposity in persons with type 2 diabetes. Research design and methods Participants with type 2 diabetes with a history of mild COVID-19 (n=15, age 58±12 years, body mass index 30.9±5.2 kg/m2) were examined before (baseline) and 1 year (12±2 months) after (follow-up) recovery from COVID-19. Investigations for changes in metabolic risk comprised clinical examination, fasting blood sampling and MR-based measurements. Potential changes were corrected with the time course of the respective parameters in a group of participants who did not contract COVID-19 over the same time course (n=14, 61±6 years, 30.0±4.6 kg/m2). Results COVID-19 resulted in a relative increase in HL content of 56% (95% CI 18%, 106%; p=0.04) measured as proton density fat fraction (HL-PDFF), corrected for the time course in the absence of COVID-19. While no changes in hepatic stiffness and volume, intramyocellular lipids, whole-body, subcutaneous and visceral adipose tissue volumes as well as homeostatic model assessment of insulin resistance and beta-cell function were observed. Conclusions History of COVID-19 in persons with type 2 diabetes is associated with higher HL-PDFF after 1 year following recovery from infection. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Kupriyanova, Y., Yurchenko, I., Bobrov, P., Bartels, F., Wierichs, S., Jonuscheit, M., Korzekwa, B., Prystupa, K., Schön, M., Mendez Cardenas, D. M., Trenkamp, S., Burkart, V., Wagner, R., Schrauwen-Hinderling, V., & Roden, M. (2025). Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes. BMJ Open Diabetes Research & Care, 13(1), Article e004727. https://doi.org/10.1136/bmjdrc-2024-004727 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 01.04.2026 | |||||||
| Dateien geändert am: | 01.04.2026 |
