Dokument: Integrative approaches for the structure‐based functional understanding of the ethylene response in plants

Titel:	Integrative approaches for the structure‐based functional understanding of the ethylene response in plants
URL für Lesezeichen:	https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72769
URN (NBN):	urn:nbn:de:hbz:061-20260331-113737-2
Kollektion:	Publikationen
Sprache:	Englisch
Dokumententyp:	Wissenschaftliche Texte » Artikel, Aufsatz
Medientyp:	Text
Autoren:	Kersten, Lisa Sophie [Autor] Eberle, Raphael Josef [Autor] Groth, Georg [Autor] Gohlke, Holger [Autor]
Dateien:	[Dateien anzeigen] Adobe PDF [Details] 1,91 MB in einer Datei [ZIP-Datei erzeugen] Dateien vom 31.03.2026 / geändert 31.03.2026
Stichwörter:	post-harvest spoilage , stress responses , ethylene signaling , copper cofactor , ethylene receptor , copper chaperones , Arabidopsis thaliana , protein–protein interactions , structural dynamics , ETR1
Beschreibung:	Ethylene is a key plant hormone regulating growth, development, and stress responses, yet the structural basis of its perception and signaling remains only partially understood. Ethylene receptors, which reside in the endomembrane network, act as dynamic signaling hubs that integrate hormone binding, copper (Cu+) cofactor coordination, and protein–protein interactions to control downstream pathways. Despite progress in characterizing individual domains, the full-length structural organization of receptors and the mechanisms linking copper (Cu+) coordination to conformational signaling remain unclear. Equally, the functional significance of receptor multimerization and higher order clustering in shaping signaling robustness and cross-talk is only beginning to emerge. To address these gaps, integrative approaches that combine struc- tural biology, advanced spectroscopic techniques, targeted mutagenesis, molecular dynamics simulations, and molecular bioinformatics are employed. Recent advances in cryo-electron microscopy (cryo-EM), cross-linking mass spectrometry, and super-resolution imaging offer unprecedented opportunities to capture conformational states, map transient receptor interfaces, and visualize clustering dynamics in living cells. Complementary structure prediction tools together with hybrid quantum/classical simulations and perturbation analyses further connect local binding events to long-range allosteric communication. This review focuses on these multidisciplinary strategies that pave the way toward a unified mechanistic frame-work of ethylene signaling.
Rechtliche Vermerke:	Originalveröffentlichung: Kersten, L. S., Eberle, R., Groth, G., & Gohlke, H. (2026). Integrative approaches for the structure‐based functional understanding of the ethylene response in plants. The Plant Journal, 125(6), Article e70810. https://doi.org/10.1111/tpj.70810
Lizenz:	Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz
Fachbereich / Einrichtung:	Mathematisch- Naturwissenschaftliche Fakultät
Dokument erstellt am:	31.03.2026
Dateien geändert am:	31.03.2026