Dokument: Demand-only energetics at 120 ATP per glucose: A reply to Lynch
| Titel: | Demand-only energetics at 120 ATP per glucose: A reply to Lynch | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72672 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260323-131301-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autor: | Martin, William F. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Energy in evolution , Biosynthetic costs , Mitochondria , Eukaryogenesis , Costs of a gene , Bioenergetics | |||||||
| Beschreibung: | Recently in these pages, a paper by Lynch appeared in response to a report showing that his numbers for biosynthetic costs (ATP demand) in cells are inflated, so much so that they would require E. coli to obtain >100 ATP per glucose and mitochondria to obtain >240 ATP per glucose. The inflated estimates trace to one factor: Lynch exclusively considers ATP demand and systematically neglects ATP supply—the essence of bioenergetics. Thermodynamics stipulate that a cell cannot grow if its ATP demands exceed its ATP supply. Here I compare Lynch's calculated ATP demands to laboratory measurements of the ATP supply that E. coli synthesizes during cell division. The results bear out my case, and leave no doubt: Lynch's calculations require E. coli to synthesize ∼120 ATP per glucose, which is thermodynamically impossible. As a consequence, his demand-only ‘energetic’ attacks on mitochondria and endosymbiosis in evolution are baseless. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Martin, W. F. (2026). Demand-only energetics at 120 ATP per glucose: A reply to Lynch. Biochimica et Biophysica Acta Bioenergetics, 1867(2), Article 149587. https://doi.org/10.1016/j.bbabio.2026.149587 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 23.03.2026 | |||||||
| Dateien geändert am: | 23.03.2026 |
