Dokument: Sociodemographic and clinical predictors of depression in children and adolescents at clinical high-risk for psychosis: Results of a two-year follow-up study
| Titel: | Sociodemographic and clinical predictors of depression in children and adolescents at clinical high-risk for psychosis: Results of a two-year follow-up study | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72665 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260323-113515-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Styss, Nick [Autor] Osman, Naweed [Autor] Walger, Petra [Autor] Meisenzahl, Eva [Autor] Reissner, Volker [Autor] Schultze-Lutter, Frauke [Autor] Michel, Chantal [Autor] Franscini, Mauricia [Autor] Traber-Walker, Nina [Autor] Schimmelmann, Benno G. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Children , Adolescents , Clinical high-risk , Comorbidity , Depression , Prediction | |||||||
| Beschreibung: | Depressive disorders are a main cause of disability already in children and adolescents, in whom the clinical picture somewhat differs from adult-onset depression. Depression is also a frequent comorbidity in somatic and mental disorders and has been considered an actionable outcome for, for example, patients at clinical high-risk for psychoses (CHRsingle bondP). Thus, we studied sociodemographic and clinical predictors of depression/dysthymia in an underage sample with focus on those considered at CHRsingle bondP. Our baseline sample (N = 676) included CHR-P patients (n = 183), inpatients admitted for non-psychotic, non-affective disorders (n = 277), and community participants (n = 216) of age 8.0–17.9 years (43.8 % male). They were interviewed for mental disorders and symptoms with various instruments, including the Mini International Neuropsychiatric Interview for Children and Adolescents, which was also used to assess depression/dysthymia in the CHR-P group at one- and two-year-follow up (n = 117/73). Stepwise logistic regression analyses were used to first identify a cross-sectional baseline model in the complete sample that was then tested prospectively in CHR-P patients. The baseline model included nationality and 13 clinical variables, particularly mild depressive symptoms. Variables contributing significantly to the prediction of persistence or new occurrence of depression/dysthymia varied over time, indicating that depression/dysthymia in CHR-P minors may require different predictors depending on the follow-up time. Furthermore, the prospective accuracy of ruling out depression/dysthymia was superior to the accuracy of ruling it in. This lower positive likelihood ratio might be overcome in future by stepwise approaches that further stratify risk in those CHR-P minors identified as at increased risk of depression/dysthymia. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Styss, N., Michel, C., Osman, N., Walger, P., Franscini, M., Traber-Walker, N., Schimmelmann, B. G., Flückiger, R., Romanos, M., Romer, G., Schulte-Körne, G., Greimel, E., Meisenzahl-Lechner, E., Reissner, V., & Schultze-Lutter, F. (2025). Sociodemographic and clinical predictors of depression in children and adolescents at clinical high-risk for psychosis: Results of a two-year follow-up study. Journal of Affective Disorders, 382, 89–97. https://doi.org/10.1016/j.jad.2025.04.002 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 23.03.2026 | |||||||
| Dateien geändert am: | 23.03.2026 |
