Dokument: Lymphotoxin beta receptor-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection
| Titel: | Lymphotoxin beta receptor-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72556 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260313-130808-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Helle, Marcel [Autor] Sorg, Ursula R. [Autor] Ptok, Johannes [Autor] Petzsch, Patrick [Autor] Köhrer, Karl [Autor] Degrandi, Daniel [Autor] Pfeffer, Klaus [Autor] Thomas, Rachel E. [Autor] Pracht, Katharina [Autor] de Bruin, Alain [Autor] | |||||||
| Dateien: |
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| Stichwörter: | B cells , lymphotoxin beta receptor , Toxoplasma gondii , bone marrow , peritoneal cavity , B-1 cells , adaptive immunity | |||||||
| Beschreibung: | Lymphotoxin β receptor (LTβR/TNFRSF3) signaling plays a crucial role in immune defense. Notably, LTβR-deficient (LTβR-/-) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to Toxoplasma gondii infection. Here, we investigated the bone marrow (BM) and peritoneal cavity (PerC) compartments of LTβR-/- mice during T. gondii infection, demonstrating perturbed B-cell and T-cell subpopulations in the absence of LTβR signaling. T. gondii infection disrupted BM lymphopoiesis, depleting early and mature B cells in WT mice, whereas mature B cells remained present in LTβR-/- BM. LTβR-/- BM also exhibited reduced MHCII+ monocytes and a plasma cell compartment skewed toward IgM+ rather than IgA+ cells. In addition, BM Tcell subsets were altered, exhibiting decreased double-negative (CD4-/CD8-) and increased CD4+ and CD8+ T-cell frequencies. Analysis of the BM transcriptome revealed diminished interferon responses but an upregulated TNFα-NF-κB signaling signature in uninfected and infected LTβR-/- mice, potentially compensating for the absence of LTβR signaling. LTβR-/- mice displayed an altered B-1a to B-1b ratio and a predominant presence of neutrophils in the PerC. In summary, we identified novel immunological alterations in the BM and PerC compartments of LTβR-/- mice, which suggest new roles for LTβR signaling in B- and T-cell homeostasis, migration, and pathogen defense. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Helle, M., Sorg, U. R., Ptok, J., Thomas, R. E., Pracht, K., Petzsch, P., de Bruin, A., Jäck, H.-M., Köhrer, K., Degrandi, D., & Pfeffer, K. D. (2025). Lymphotoxin beta receptor-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection. Infection and Immunity, 93(10), Article e00408-25. https://doi.org/10.1128/iai.00408-25 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 13.03.2026 | |||||||
| Dateien geändert am: | 13.03.2026 |
