Dokument: Heterotypic phase separation in aggregation: Driver or deterrent?
| Titel: | Heterotypic phase separation in aggregation: Driver or deterrent? | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=72328 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260218-112755-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Jacob, Tina [Autor] Hoyer, Wolfgang [Autor] | |||||||
| Dateien: |
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| Stichwörter: | α-Synuclein , Heterotypic condensates , Tau protein , Liquid–liquid phase separation (LLPS) , Protein aggregation , Neurodegenerative diseases | |||||||
| Beschreibung: | Liquid–liquid phase separation (LLPS) of proteins implicated in neurodegenerative diseases has gained growing attention in recent years, due to its potential role in driving the transition from functional protein monomers to pathogenic aggregates. However, the mechanisms by which phase separation contributes to the loss of protein function and promotes aggregation remain poorly understood. Recent studies show that multiple proteins or other biomolecules can colocalize within the biomolecular condensates, creating a highly interactive microenvironment that can modulate aggregation. In this review we look into the heterotypic phase separation of tau and α-synuclein, the two key proteins responsible for critical neurodegenerative disorders. By compiling recent findings, this review highlights the modulatory role of heterotypic condensates in disease progression and aims to provide an alternative perspective on regulation of protein aggregation in neurodegeneration. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Jacob, T., & Hoyer, W. (2026). Heterotypic phase separation in aggregation: Driver or deterrent? Biophysical Chemistry, 331, Article 107577. https://doi.org/10.1016/j.bpc.2026.107577 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 18.02.2026 | |||||||
| Dateien geändert am: | 18.02.2026 |
