Dokument: Effects of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: results of a randomized, sham-controlled pilot trial
| Titel: | Effects of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: results of a randomized, sham-controlled pilot trial | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=71884 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20260114-133956-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Kujovic, Milenko [Autor] Bahr, Christian [Autor] Riesbeck, Mathias [Autor] Benz, Daniel [Autor] Wingerter, Lena [Autor] Deiß, Martina [Autor] Margittai, Zsofia [Autor] Reinermann, Dirk [Autor] Meisenzahl-Lechner, Eva [Autor] Plewnia, Christian [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | Dialectical Behavior Therapy , Borderline Personality Disorder , iTBS , rTMS | |||||||
| Beschreibung: | Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in borderline personality disorder (BPD). We hypothesized that intermittent theta burst stimulation (iTBS), a modified rTMS protocol that provides unilateral stimulation to the left dorsolateral prefrontal cortex, would enhance the effects of DBT and reduce BPD-specific symptoms more than sham stimulation. We performed a single-blind, randomized, sham-controlled pilot study to evaluate iTBS as an add-on to 8-week DBT for BPD in routine inpatient treatment. A total of 53 BPD patients were randomly assigned to either iTBS (n = 25) or sham stimulation (n = 28) in weeks 4–8 of DBT; 40 patients were eligible for inclusion in the analyses according to pre-specified criteria (≥ 16 of 20 iTBS sessions). The primary endpoint was change on the 23-item Borderline Symptom List; secondary endpoints were changes in depressive symptoms and general level of functioning. A mixed model repeated measures analysis with a 2 × 2 factorial between-subjects design showed no significant effect of add-on iTBS treatment, but a distinct trend was observed in favor of iTBS (Cohen’s d = 0.23 for group difference). We found a main effect of DBT with and without iTBS over time, indicating efficacy of 8 weeks’ DBT (d = 0.89–1.12). iTBS may be beneficial as an add-on to DBT in the long term and warrants further evaluation in larger studies. Trial registration Registered at drks.de (no. DRKS00020413) on January 13, 2020. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Kujovic, M., Bahr, C., Riesbeck, M., Benz, D., Wingerter, L., Deiß, M., Margittai, Z., Reinermann, D., Plewnia, C., & Meisenzahl-Lechner, E. (2024). Effects of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: results of a randomized, sham-controlled pilot trial. European Archives of Psychiatry + Clinical Neuroscience, 275(8), 2301–2314. https://doi.org/10.1007/s00406-024-01901-0 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 14.01.2026 | |||||||
| Dateien geändert am: | 14.01.2026 |
