Dokument: New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray
| Titel: | New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=71449 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20251120-125610-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Le, Kim Thao [Autor] Bandolik, Jan Josef [Autor] Kassack, Matthias U. [Autor] Paßreiter, Claus [Autor] Wood, Kenneth R. [Autor] Paetzold, Claudia [Autor] Appelhans, Marc S. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | acetophenones , melibarbinon A and B , Rutaceae , melibarbichromen A and B , ovarian cancer cell line A2780 , chromenes , cytotoxicity , Melicope barbigera | |||||||
| Beschreibung: | The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua’i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher’s method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 µM for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Le, K. T., Bandolik, J. J., Kassack, M., Wood, K. R., Paetzold, C., Appelhans, M. S., & Paßreiter, C. (2021). New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray [OnlineRessource]. Molecules, 26(3), Article 688. https://doi.org/10.3390/molecules26030688 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 20.11.2025 | |||||||
| Dateien geändert am: | 20.11.2025 |
