Dokument: Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize
| Titel: | Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=71427 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20251119-105403-2 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Engelhorn, Julia [Autor] Kok, Amelie [Autor] Schneider, Michael [Autor] Kiwit, Tatjana [Autor] Doan, Duong Hi Thi [Autor] Stich, Benjamin [Autor] Frommer, Wolf B. [Autor] Hartwig, Thomas [Autor] Snodgrass, Samantha J. [Autor] Seetharam, Arun S. [Autor] | |||||||
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| Beschreibung: | Comprehensive maps of functional variation at transcription factor (TF) binding sites (cis-elements) are crucial for elucidating how genotype shapes phenotype. Here, we report the construction of a pan-cistrome of the maize leaf under well-watered and drought conditions. We quantified haplotype-specific TF footprints across a pan-genome of 25 maize hybrids and mapped over 200,000 variants, genetic, epigenetic, or both (termed binding quantitative trait loci (bQTL)), linked to cis-element occupancy. Three lines of evidence support the functional significance of bQTL: (1) coincidence with causative loci that regulate traits, including vgt1, ZmTRE1 and the MITE transposon near ZmNAC111 under drought; (2) bQTL allelic bias is shared between inbred parents and matches chromatin immunoprecipitation sequencing results; and (3) partitioning genetic variation across genomic regions demonstrates that bQTL capture the majority of heritable trait variation across ~72% of 143 phenotypes. Our study provides an auspicious approach to make functional cis-variation accessible at scale for genetic studies and targeted engineering of complex traits. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Engelhorn, J., Snodgrass, S. J., Kok, A. L., Seetharam, A. S., Schneider, M., Kiwit, T., Singh, A., Banf, M., Doan, D. H. T., Khaipho-Burch, M., Runcie, D. E., Sánchez-Camargo, V. A., Bader, R., Vladimir Torres-Rodriguez, J., Sun, G., Stam, M., Fiorani, F., Beier, S., Schnable, J. C., … Hartwig, T. (2025). Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize. Nature Genetics, 57(9), 2313–2322. https://doi.org/10.1038/s41588-025-02246-7 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 19.11.2025 | |||||||
| Dateien geändert am: | 19.11.2025 |
