Dokument: Monitoring copper ions in C. elegans using porphyrin phosphonic acids
| Titel: | Monitoring copper ions in C. elegans using porphyrin phosphonic acids | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=71311 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20251111-123304-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Tholen, Patrik [Autor] Müller, Tim [Autor] Fabrizi, Jonas [Autor] Yücesan, Gündog [Autor] Weishaupt, Ann-Kathrin [Autor] Schmitt, Franz-Josef [Autor] Nguyen, Tuong V. M. [Autor] Keil, Claudia [Autor] Maares, Maria [Autor] Schomburg, Lutz [Autor] | |||||||
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| Beschreibung: | Herein we report a charge-assisted hydrogen bonded organic framework (HOF) built with an extended tethered phosphonic acid namely 5,10,15,20-Tetra-(4’-yl-[1’,1”-biphenyl]−4”phosphonic acid) porphyrin (p-H8-TBPPA) and phenyl phosphonic acid (PPA). Metal responsive fluorescent properties of the linker p-H8-TBPPA with biologically significant transition metal ions (Zn2+, Cu2+, Ni2+, Co2+, Fe2+, Mn2+) and heavy metal ions (Hg2+, Pb2+, Cd2+) is further characterized. p-H8-TBPPA shows distinct fluorescence responses for each metal ion with very specific decreases in intensity for the different analytes, and the strong turn off fluorescence of p-H8-TBPPA in presence of copper is used to monitor copper ion homeostasis in C. elegans. p-H8-TBPPA is also found to be non-toxic for Caco-2 cells and C. elegans at concentrations required for fluorescence measurements. These findings establish p-H8-TBPPA as a promising platform for the development of in vivo metal ion sensors, with potential applications in diagnostic imaging, and environmental monitoring. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Tholen, P., Weishaupt, A.-K., Schmitt, F.-J., Müller, T., Fabrizi, J., Nguyen, T. V. M., Keil, C., Maares, M., Schomburg, L., Haase, H., Zorlu, Y., Beckmann, J., Bornhorst, J., & Yücesan, G. (2025). Monitoring copper ions in C. elegans using porphyrin phosphonic acids. Communications Materials, 6, Article 228. https://doi.org/10.1038/s43246-025-00975-0 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 11.11.2025 | |||||||
| Dateien geändert am: | 11.11.2025 |
