Dokument: Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization
| Titel: | Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=70781 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250917-102519-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Gruchot, Joel [Autor] Reiche, Laura [Autor] Werner, Luisa [Autor] Herrero, Felisa [Autor] Schira-Heinen, Jessica [Autor] Meyer, Urs [Autor] Küry, Patrick [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Human endogenous retrovirus type W , Neuroinflammation , Multiple sclerosis , Neurodegeneration , Glia | |||||||
| Beschreibung: | The endogenous retrovirus type W (HERV-W) is a human-specific entity, which was initially discovered in multiple sclerosis (MS) patient derived cells. We initially found that the HERV-W envelope (ENV) protein negatively affects oligodendrogenesis and controls microglial cell polarization towards a myelinated axon associated and damaging phenotype. Such first functional assessments were conducted ex vivo, given the human-specific origin of HERV-W. Recent experimental evidence gathered on a novel transgenic mouse model, mimicking activation and expression of the HERV-W ENV protein, revealed that all glial cell types are impacted and that cellular fates, differentiation, and functions were changed. In order to identify HERV-W-specific signatures in glial cells, the current study analyzed the transcriptome of ENV protein stimulated microglial- and astroglial cells and compared the transcriptomic signatures to lipopolysaccharide (LPS) stimulated cells, owing to the fact that both ligands can activate toll-like receptor-4 (TLR-4). Additionally, a comparison between published disease associated glial signatures and the transcriptome of HERV-W ENV stimulated glial cells was conducted. We, therefore, provide here for the first time a detailed molecular description of specific HERV-W ENV evoked effects on those glial cell populations that are involved in smoldering neuroinflammatory processes relevant for progression of neurodegenerative diseases. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Gruchot, J., Reiche, L., Werner, L., Herrero, F., Schira-Heinen, J., Meyer, U., & Küry, P. (2024). Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization. Microbes and Infection, 27(5–6), Article 105382. https://doi.org/10.1016/j.micinf.2024.105382 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 17.09.2025 | |||||||
| Dateien geändert am: | 17.09.2025 |
