Dokument: Nivolumab Induces Durable Remission in Relapsed/Refractory ALK‐Negative ALCL After Allogeneic Blood Stem Cell Transplantation—A Case Report and Literature Review
| Titel: | Nivolumab Induces Durable Remission in Relapsed/Refractory ALK‐Negative ALCL After Allogeneic Blood Stem Cell Transplantation—A Case Report and Literature Review | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=70297 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250722-124100-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Bärmann, Ben-Niklas [Autor] Nachtkamp, Kathrin [Autor] Jäger, Paul [Autor] Kessler, Paula [Autor] Novruzov, Emil [Autor] Giesel, Frederik L. [Autor] Peters, Helena A. [Autor] Seidl, Maximilian [Autor] Uhlenbruch, Mark [Autor] Dietrich, Sascha [Autor] | |||||||
| Dateien: |
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| Stichwörter: | GVHD, T-cell lymphoma, stem cell transplantation, case report | |||||||
| Beschreibung: | Background:
Relapsed or refractory anaplastic large cell lymphoma (r/r-ALCL) remains an important therapeutic challenge, especially after allogeneic stem cell transplantation (alloHSCT). Due to encouraging results in other lymphoid diseases, PD-1 blockade was investigated in T-cell lymphoma in a small number of patients, but short duration of remission and significant adverse events were observed. Case Report: Here, we report successful and durable remission induction for more than 2 years with nivolumab for r/r-ALCL even without any evidence of PD-L1 expression. Conclusion: This report and literature review emphasizes the importance of the graft-versus-lymphoma effect and its potential pharmacological stimulators in the field of lymphoma treatment | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Bärmann, B.-N., Nachtkamp, K., Jäger, P. S., Kessler, P., Novruzov, E., Giesel, F. L., Peters, H. A., Seidl, M., Uhlenbruch, M., Dietrich, S., & Kobbe, G. (2025). Nivolumab Induces Durable Remission in Relapsed/Refractory ALK‐Negative ALCL After Allogeneic Blood Stem Cell Transplantation—A Case Report and Literature Review. EJHaem, 6(3), Article e70041. https://doi.org/10.1002/jha2.70041 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 22.07.2025 | |||||||
| Dateien geändert am: | 22.07.2025 |
