Dokument: Generation of an induced pluripotent stem cell line HHUUKDi013-A (ISRM-AATD-iPSC-3) from a pediatric patient of Alpha-I Antitrypsin Deficiency (AATD)
| Titel: | Generation of an induced pluripotent stem cell line HHUUKDi013-A (ISRM-AATD-iPSC-3) from a pediatric patient of Alpha-I Antitrypsin Deficiency (AATD) | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=70232 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250717-115523-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Loerch, Christiane [Autor] Hokamp, Rabea [Autor] Wruck, Wasco [Autor] Katzer, David [Autor] Weigert, Alexander [Autor] Machui, Alexander [Autor] Graffmann, Nina [Autor] Ganschow, Rainer [Autor] Adjaye, James [Autor] | |||||||
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| Beschreibung: | Renal progenitor cells were isolated from urine from a male, pediatric AATD-patient, harboring the homologous Pi*ZZ genotype. SIX2-positive urine derived renal progenitor cells (UdRPCs) were reprogrammed to iPSCs by integration-free nucleofection of episomal-based plasmids expressing OCT4, KLF4, c-MYC, SOX2, NANOG and LIN28. ISRM-AATD-iPSC-3 show pluripotent gene and protein expression, are capable of forming embryoid bodies and carry the parental Pi*ZZ genotype. Global transcriptome analyses revealed a correlation coefficient 0.9091 between the human embryonic stem cell line H9 and ISRM-AATD-iPSC-3. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Lörch, C., Hokamp, R., Wruck, W., Katzer, D., Weigert, A., Machui, A., Graffmann, N., Ganschow, R., & Adjaye, J. (2025). Generation of an induced pluripotent stem cell line HHUUKDi013-A (ISRM-AATD-iPSC-3) from a pediatric patient of Alpha-I Antitrypsin Deficiency (AATD). Stem Cell Research, 87, Article 103762. https://doi.org/10.1016/j.scr.2025.103762 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 17.07.2025 | |||||||
| Dateien geändert am: | 17.07.2025 |
