Dokument: Matched‐pair analysis of peri‐operative and oncological outcomes of robot‐assisted vs open retroperitoneal lymph node dissection
| Titel: | Matched‐pair analysis of peri‐operative and oncological outcomes of robot‐assisted vs open retroperitoneal lymph node dissection | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69973 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250624-114520-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Pongratanakul, Pailin [Autor] Vermeulen-Spohn, Marieke [Autor] Wöltjen, Carolin [Autor] Thy, Sophia [Autor] Hiester, Andreas [Autor] Albers, Peter [Autor] Che, Yue [Autor] | |||||||
| Dateien: |
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| Stichwörter: | germ cell tumours, robot-assisted RPLND, testicular cancer, robotic surgery, oncological outcome, retroperitoneal lymph node dissection | |||||||
| Beschreibung: | Objective
To analyse a comparatively large cohort of patients who underwent robot-assisted retroperitoneal lymph node dissection (R-RPLND) in a single centre, assessing the peri-operative and oncological safety of this procedure compared to that in a matched-pair cohort of patients who underwent open retroperitoneal lymph node dissection (O-RPLND). Methods We retrospectively identified 100 patients who underwent R-RPLND between October 2010 and January 2024. A matched-pair analysis of R-RPLNDs and O-RPLNDs was conducted based on the following criteria: surgical indication, histology, clinical stage (CS), and tumour size. The primary endpoint of this analysis was progression-free survival (PFS). Secondary endpoints were peri-operative parameters. Results Based on surgical indication, the R-RPLND cohort was divided into four groups: CS II seminoma (Group 1, 42 patients); marker-negative CS II non-seminoma (Group 2, 15 patients); CS I non-seminoma with high-risk factors (Group 3, seven patients), and post-chemotherapy patients (Group 4, 34 patients). Two patients were excluded due to uncommon testicular histology. With a mean follow-up of 32, 31, 32 and 28 months in the four groups, respectively, relapses occurred in 10/42 of Group 1, 3/15 of Group 2, and 1/7 of Group 3, while all patients remained relapse-free in Group 4. The matched-pair analysis revealed that histological retroperitoneal lymph node dissection specimens, relapse rates, and PFS were similar in the R-RPLND and O-RPLND groups. R-RPLND had advantages in terms of a shorter hospital stay as a surrogate for less morbidity. Conclusion In selected patients and selected surgical indications, R-RPLND represents a minimally invasive alternative to O-RPLND in the management of patients with testicular germ cell tumours. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Pongratanakul, P., Vermeulen, M., Wöltjen, C., Thy, S., Hiester, A., Albers, P., & Che, Y. (2025). Matched‐pair analysis of peri‐operative and oncological outcomes of robot‐assisted vs open retroperitoneal lymph node dissection. BJU International, 136(1), 150–158. https://doi.org/10.1111/bju.16747 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 24.06.2025 | |||||||
| Dateien geändert am: | 24.06.2025 |
