Dokument: Distinct HLA Haplotypes Are Associated With an Altered Strength of SARS‐CoV‐2‐Specific T‐Cell Responses and Unfavorable Disease Courses
| Titel: | Distinct HLA Haplotypes Are Associated With an Altered Strength of SARS‐CoV‐2‐Specific T‐Cell Responses and Unfavorable Disease Courses | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69809 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250605-114434-8 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Dörnte, C. [Autor] Datsi, Angeliki [Autor] Traska, V. [Autor] Kostyra, J. [Autor] Wagner, M. [Autor] Brauns, O. [Autor] Lamsfuß, C. [Autor] Winkels, H. [Autor] Balz, Vera [Autor] Enczmann, Jürgen [Autor] | |||||||
| Dateien: |
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| Stichwörter: | APC, SARS-CoV-2, T-cell immunity, NetMHCpan, HLA haplotypes | |||||||
| Beschreibung: | Infection with SARS-CoV-2 results in mild to severe COVID-19 disease courses. Several studies showed the association of impaired T-cell responses and certain HLA haplotypes with disease severity. However, it remained unclear if T-cell activation was compromised due to a general reduction of presented epitopes or other intrinsic factors within APCs or T cells. Furthermore, a potential reduction of presented epitopes would suggest if an upcoming SARS-CoV-2 variant could escape T-cell immunity. Hence, knowledge about the T-cell epitope landscape of SARS-CoV-2 would allow to better understand mechanisms leading to severe disease and to estimate the potential stability of the T-cell response in light of virus evolution, which might provide insights for future vaccine designs. Hence, in the present study, the T-cell epitope landscape of SARS-CoV-2 was determined via in vitro T-cell stimulation plus in silico prediction. HLAs associated with mild and severe disease courses showed almost the same potential in epitope presentation, suggesting intrinsic factors of APCs or T cells as contributors to the more severe disease courses. As T-cell epitopes did also not originate from regions of SARS-CoV-2 having shown high mutation rates in the past, a relatively stable T-cell response can be expected regarding new SARS-CoV-2 strains in the future. Analysis of the T-cell epitope landscape of SARS-CoV-2 suggests T-cell intrinsic factors as likely modulators of disease severity and that the capacity of MHC-peptide presentation remains stable among circulating SARS-CoV-2 viral strains. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Dörnte, C., Datsi, A., Traska, V., Kostyra, J., Wagner, M., Brauns, O., Lamsfuß, C., Winkels, H., Balz, V., Enczmann, J., Adams, O., Müller, L., Baurmann, H., Eiz‐Vesper, B., Bonifacius, A., Sorg, R., Dose, C., Schmitz, J., Richter, A., … Schuster, M. (2025). Distinct HLA Haplotypes Are Associated With an Altered Strength of SARS‐CoV‐2‐Specific T‐Cell Responses and Unfavorable Disease Courses. European Journal of Immunology, 55(4), Article e202451497. https://doi.org/10.1002/eji.202451497 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 05.06.2025 | |||||||
| Dateien geändert am: | 05.06.2025 |
