Dokument: One‐Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α‐Perfluoroalkenylation
| Titel: | One‐Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α‐Perfluoroalkenylation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69732 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250526-111710-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Zhu, Yu-Jun [Autor] Czekelius, Constantin [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Fluorinated heterocycles, Pyrimidines, Aldehydes, One-pot synthesis, Photocatalysis | |||||||
| Beschreibung: | A straightforward, operationally simple and inexpensive one-
pot synthesis of substituted 4-perfluoroalkyl-pyrimidine deriva- tives is reported. Employing triphenylphosphine as a photo- catalyst and an additional imidazolidinone organocatalyst, aldehydes undergo α-perfluoroalkenylation giving highly elec- tron-deficient enals, which form the heterocycle upon con- densation with a guanidinium salt. The method tolerates many functional groups and gives the corresponding products in up to 84 % yield over both steps. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Zhu, Y.-J., & Czekelius, C. (2025). One‐Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α‐Perfluoroalkenylation. European Journal of Organic Chemistry, 28(17), Article e202500047. https://doi.org/10.1002/ejoc.202500047 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 26.05.2025 | |||||||
| Dateien geändert am: | 26.05.2025 |
