Dokument: Polypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine
| Titel: | Polypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69632 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250514-105056-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Moellmann, Henriette L. [Autor] Boulghoudan, Soufian [Autor] Kuhlmann, Julian Max [Autor] Rahm, Louisa [Autor] Frohnhofen, Helmut [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Postoperatives Delir, Chirurgie, Anticholinerge Belastung, Geriatrisches Assessment, Anticholinergic burden, Polypharmacy, Geriatric assessment, Polypharmazie, Postoperative delirium, Surgery | |||||||
| Beschreibung: | Purpose
Polypharmacy is a widespread phenomenon in older patients. In particular, the anticholinergic burden of medication is an important risk factor for delirium due to age-related changes in the cholinergic system. Methods Preoperative medication, including the calculation of the anticholinergic burden (ACB), was recorded in a prospective study (421 patients) to identify potential risks associated with medication intake. Postoperative delirium screening was carried out daily. Results The study included 199 women (47.3%) and 222 men (52.7%) aged 80.8 ± 6.7 years and 78.8 ± 6.2 years, respectively. Antidepressants odds ratio (OR) 3.16 (95% confidence interval. CI, 1.51–6.64), antidiabetic drugs OR 2.53 (95% CI 1.27–5.03), neuroleptics OR 3.52 (95% CI 1.70–7.28) and Parkinson medication OR 5.88 (95% CI 1.95–17.7) showed a significantly higher risk for delirium. The ACB score revealed an anticholinergic burden in 43 patients (10.4%). The delirium rate was 25.6% (n = 11) and 11.0% (n = 40) had no anticholinergic burden. A significant correlation can be demonstrated with χ2(1) = 7.52, p = 0.006, Cramer’s V = 0.136. There was a 2.79-fold higher risk of delirium (OR 2.79, 95% CI 1.31–5.97). Conclusion The standardized recording of medication is essential, especially when identifying patients at risk of suffering from delirium. The use of the ACB score to assess the anticholinergic burden is a simple and reliable screening tool and should be part of a preoperative geriatric assessment. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Möllmann, H., Boulghoudan, S., Kuhlmann, J. M., Rahm, L., & Frohnhofen, H. (2025). Polypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine. Zeitschrift Für Gerontologie + Geriatrie, 58(3), 203–208. https://doi.org/10.1007/s00391-024-02388-z | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 14.05.2025 | |||||||
| Dateien geändert am: | 14.05.2025 |
