Dokument: Haploidentical Allogeneic Stem Cell Transplantation as a Superior Alternative for Patients With Mismatch Donors—A Single Center Experience in 152 Patients
| Titel: | Haploidentical Allogeneic Stem Cell Transplantation as a Superior Alternative for Patients With Mismatch Donors—A Single Center Experience in 152 Patients | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69620 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250512-112815-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Jäger, Paul [Autor] Biermann, Benno [Autor] Liebers, Nora [Autor] Schulz, Felicitas [Autor] Baermann, Ben-Niklas [Autor] Twarock, Sören [Autor] Geyh, Stefanie [Autor] Nachtkamp, Kathrin [Autor] Tressin, Patrick [Autor] Kasprzak, Annika [Autor] | |||||||
| Dateien: |
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| Stichwörter: | cellular therapies, hematological malignancies, transplant, BMT | |||||||
| Beschreibung: | Background: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a key treatment for hematologic malignancies, but donor selection impacts outcomes.
Results: In a cohort of 152 patients undergoing allo-SCT from 2012 to 2023, haploidentical donors with post-transplant cyclophosphamide (PTCy) showed superior survival compared to 9/10 mismatched unrelated donors (MMUD). Cox regression analysis revealed that patients not in complete remission (CR) before transplantation particularly benefited from haplo donors, while those with 9/10 MMUD and lacking CR had worse outcomes. Conclusion: These results highlight the importance of donor selection, suggesting that haplo donors with PTCy may be preferable for patients not in CR, necessitating alternative approaches for others. Clinical trial registration: The authors have confirmed clinical trial registration is not needed for this submission. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Jäger, P. S., Biermann, B., Liebers, N., Schulz, F., Bärmann, B.-N., Twarock, S., Geyh, S., Nachtkamp, K., Tressin, P., Kasprzak, A., Matkey, F., Watrin, T., El Yaouti, M., Germing, U., Dietrich, S., & Kobbe, G. (2025). Haploidentical Allogeneic Stem Cell Transplantation as a Superior Alternative for Patients With Mismatch Donors—A Single Center Experience in 152 Patients. EJHaem [ISSN: 2688-6146], 6(2). https://doi.org/10.1002/jha2.70012 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 12.05.2025 | |||||||
| Dateien geändert am: | 12.05.2025 |
