Dokument: Blood flow‐induced angiocrine signals promote organ growth and regeneration
| Titel: | Blood flow‐induced angiocrine signals promote organ growth and regeneration | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69619 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250512-111121-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Follert, Paula [Autor] Große-Segerath, Linda [Autor] Lammert, Eckhard [Autor] | |||||||
| Dateien: |
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| Stichwörter: | angiocrine signals, organ growth, blood flow, regeneration, Myeloid-derived growth factor (MYDGF), liver | |||||||
| Beschreibung: | Recently, we identified myeloid-derived growth factor (MYDGF) as a blood flow-induced angiocrine signal that promotes human and mouse hepatocyte proliferation and survival. Here, we review literature reporting changes in blood flow after partialorgan resection in the liver, lung, and kidney, and we describe the angiocrine signals released by endothelial cells (ECs) upon blood flow alterations in these organs.
While hepatocyte growth factor (HGF) and MYDGF are important angiocrine signals for liver regeneration, by now, angiocrine signals have also been reported to stimulate hyperplasia and/or hypertrophy during the regeneration of lungs and kidneys. In addition, angiocrine signals play a critical role in tumor growth. Understanding the mechano-elastic properties and flow-mediated alterations in the organ-specific microvasculature is crucial for therapeutic approaches to maintain organ health and initiate organ renewal. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Follert, P., Große-Segerath, L., & Lammert, E. (2024). Blood flow‐induced angiocrine signals promote organ growth and regeneration. Bioessays, 47(2), Article 2400207. https://doi.org/10.1002/bies.202400207 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 12.05.2025 | |||||||
| Dateien geändert am: | 12.05.2025 |
