Dokument: Interleukin‐11 receptor is an alternative α‐receptor for interleukin‐6 and the chimeric cytokine IC7
| Titel: | Interleukin‐11 receptor is an alternative α‐receptor for interleukin‐6 and the chimeric cytokine IC7 | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69618 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250512-102123-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Weitz, Hendrik T. [Autor] Ettich, Julia [Autor] Rafii, Puyan [Autor] Wittich, Christoph [Autor] Schultz, Laura [Autor] Frank, Nils C. [Autor] Heise, Denise [Autor] Krusche, Matthias [Autor] Lokau, Juliane [Autor] Garbers, Christoph [Autor] | |||||||
| Dateien: |
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| Stichwörter: | cytokine, gp130, interleukin 6, IL-11, cross-talk | |||||||
| Beschreibung: | The cytokine interleukin 6 (IL-6) signals via the IL-6 α-receptor (IL-6Rα or IL-6R) in complex with the gp130 β-receptor. Cell type restricted expression of the IL-6R limits the action of IL-6 mainly to hepatocytes and some immune cells. Here, we show that IL-6 also binds to the IL-11 α receptor (IL-11Rα or IL-11R) and induces signaling via IL-11R:gp130 complexes, albeit with a lower affinity compared to IL-11. Antagonistic antibodies directed against IL-11R, but not IL-6R, inhibit IL-6 signaling via IL-11R: gp130 receptor complexes. Notably, IL-11 did not cross-react with IL-6R. IL-11R has also been identified as an alternative α receptor for the CNTF/IL-6-derived chimeric cytokine IC7, which has recently been shown to induce weight loss in mice. Accordingly, the effects of therapeutic monoclonal antibodies against IL-6 or IL-6R, which both block IL-6 signaling, may be slightly different. These findings provide new insights into IL-6 signaling and therefore offer new potential therapeutic intervention options in the future | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Weitz, H. T., Ettich, J., Rafii, P., Wittich, C., Schultz, L., Frank, N. C., Heise, D., Krusche, M., Lokau, J., Garbers, C., Behnke, K., Floß, D. M., Kolmar, H., Moll, J. M., & Scheller, J. (2024). Interleukin‐11 receptor is an alternative α‐receptor for interleukin‐6 and the chimeric cytokine IC7. The FEBS Journal / Federation of European Biochemical Societies, 292(3), 523–536. https://doi.org/10.1111/febs.17309 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät Medizinische Fakultät | |||||||
| Dokument erstellt am: | 12.05.2025 | |||||||
| Dateien geändert am: | 12.05.2025 |
