Dokument: The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining
| Titel: | The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69594 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250507-112316-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Mastrototaro, Lucia [Autor] Apostolopoulou, Maria [Autor] Hartwig, Sonja [Autor] Strassburger, Klaus [Autor] Lipaeva, Polina [Autor] Trinks, Nina [Autor] Karusheva, Yanislava [Autor] Gancheva, Sofiya [Autor] Trenkamp, Sandra [Autor] Lehr, Stefan [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Small extracellular vesicles, Exercise, Detraining, Inter-organ crosstalk, Insulin sensitivity | |||||||
| Beschreibung: | Background
High-intensity interval training (HIIT) has been shown to improve cardiorespiratory fitness ( O2 max) but may ameliorate insulin sensitivity only in insulin-resistant humans. It is yet unclear whether these benefits persist after detraining and to which extent duration and effectiveness of metabolic improvements differ between individuals without and with prediabetes or type 2 diabetes (T2D). Understanding these differences is relevant for developing targeted exercise training modes for individuals with different stages of dysglycemia. Methods Men with (20 T2D) and without T2D (12 insulin-sensitive, IS-NDM; 10 insulin-resistant, IR-NDM) underwent hyperinsulinemic-euglycemic clamps, spiroergometry, ectopic lipid quantification and muscle biopsies at baseline, after 12-week HIIT and after 4-week detraining. Findings After detraining, the HIIT-stimulated O2 max declined in T2D and IR-NDM, but remained higher compared to baseline in all groups. The HIIT-induced changes in hepatic insulin sensitivity and ectopic lipid content were sustained after detraining in T2D and IR-NDM, whereas improvements of whole-body insulin sensitivity were abolished in T2D. T2D and IR-NDM showed persistent increases in the number of small extracellular vesicles, which carry among others antioxidant proteins. The ratio of reduced-to-oxidized glutathione further decreased after detraining in all groups, whereas changes in proteins involved in mitochondrial turnover were dependent on insulin sensitivity, with some evidence for upregulation of fusion and mitophagy in T2D and IR-NDM and upregulation of fission in IS-NDM. Levels of different lipolytic proteins were reduced in all participants after detraining. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Mastrototaro, L., Apostolopoulou, M., Hartwig, S., Strassburger, K., Lipaeva, P., Trinks, N., Karusheva, Y., Gancheva, S., Trenkamp, S., Lehr, S., Al-Hasani, H., Szendroedi, J., & Roden, M. (2024). The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining. EBioMedicine, 110, Article 105471. https://doi.org/10.1016/j.ebiom.2024.105471 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 07.05.2025 | |||||||
| Dateien geändert am: | 07.05.2025 |
