Dokument: Extended mesenteric resection reduces the rate of surgical recurrence in Crohn’s disease: a systematic review and meta-analysis
| Titel: | Extended mesenteric resection reduces the rate of surgical recurrence in Crohn’s disease: a systematic review and meta-analysis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69353 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250414-114635-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Vaghiri, Sascha [Autor] Alipouriani, Ali [Autor] Knoefel, Wolfram Trudo [Autor] Kessler, Hermann [Autor] Prassas, Dimitrios [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Crohn’s disease, Complications, Recurrence rate, Mesenteric resection | |||||||
| Beschreibung: | Purpose
Mesenteric resection in Crohn’s disease (CD) is still controversial and under discussion. We performed a meta-analysis to assess recurrence rates and operative-related morbidity based on the extent of mesenteric resection. Methods A comprehensive literature research was conducted until November 2024 using PubMed (Medline), the Cochrane Central trials register, and Google Scholar databases. Studies before the biological era or with Kono-S anastomosis were excluded. Data from comparative studies with reported patient characteristics and outcome results of extended and limited mesenteric resections were extracted and subsequently entered into a pairwise meta-analysis model. Odds ratios (ORs) for dichotomous variables and standardized mean differences (SMDs) for continuous outcomes with 95% confidence intervals (CIs) were calculated. The risk of bias was rated according to ROBINS-I and Rob2 criteria, respectively. Results Four non-randomized studies and one randomized trial with a total of 4358 patients (extended mesenteric resection: n = 993 versus mesenteric preservation: n = 3365) met eligibility criteria and were included. Extended mesenteric resection was significantly associated with reduced surgical recurrence rates compared to mesenteric preservation (OR = 4.94; 95% CI [2.22–10.97]; p < 0.001, I2 = 0%). In terms of endoscopic recurrence, postoperative morbidity, and hospital stay, no significant differences between both groups were noted within the short follow-up period. Conclusion Extended mesenteric resection demonstrated a lower surgical recurrence rate in Crohn’s disease, while morbidity rates were comparable to the mesenteric sparing approach, whether extended mesenteric excision should be recommended requires further high-quality randomized trials with long-term follow-up data. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Vaghiri, S., Alipouriani, A., Knoefel, W. T., Kessler, H., & Prassas, D. (2025). Extended mesenteric resection reduces the rate of surgical recurrence in Crohn’s disease: a systematic review and meta-analysis. International Journal of Colorectal Disease, 40, Article 51. https://doi.org/10.1007/s00384-025-04845-6 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 14.04.2025 | |||||||
| Dateien geändert am: | 14.04.2025 |
