Dokument: Diaphragmatic stripping versus full-thickness diaphragmatic resection in cytoreductive surgery: a meta-analysis of the current evidence
| Titel: | Diaphragmatic stripping versus full-thickness diaphragmatic resection in cytoreductive surgery: a meta-analysis of the current evidence | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69294 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250410-124038-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Stylianidi, Maria Chiara [Autor] Vaghiri, Sascha [Autor] Pandkhahi, Alireza [Autor] Kazziha, Sultan [Autor] Al Akeel, Ward [Autor] Knoefel, Wolfram Trudo [Autor] Prassas, Dimitrios [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Peritoneal carcinomatosis, Diaphragmatic stripping, Full thickness diaphragmatic resection, Diaphragmatic surgery, Cytoreductive surgery, Pulmonary complications | |||||||
| Beschreibung: | Purpose
The primary objective was to compare the intra- and postoperative outcomes of diaphragmatic stripping versus full-thickness diaphragmatic resection in patients with peritoneal carcinomatosis who underwent cytoreductive surgery. Methods According to the PRSIMA guidelines, a comprehensive literature search was conducted for studies comparing postoperative pulmonary complications as well as intra- and postoperative outcomes of diaphragmatic stripping versus full-thickness diaphragmatic resection in patients with peritoneal carcinomatosis necessitating cytoreductive surgery. Data from eligible studies were extracted, qualitatively assessed, and included in a meta-analysis. Odds ratios (ORs) and standardized mean differences (SMDs) with 95 per cent confidence intervals were calculated. Results Ten studies with 1325 patients were included in this meta-analysis. Diaphragmatic stripping was associated with lower incidence of pleural effusion (OR 0.47, 95% CI 0.35–0.63, p < 0.00001) and pneumothorax (OR 0.52, 95% CI 0.35–0.78, p = 0.002), less severe postoperative complications (Clavien-Dindo Grade ≥ 3) (OR 0.43, 95% CI 0.30–0.63, p < 0.0001), and shorter duration of surgery (SMD -0.31, 95% CI -0.54 – -0.08, p = 0.007). No significant differences were observed in postoperative subdiaphragmatic abscess occurrence, intraoperative blood loss, hospital- and ICU-stay, and 90-day mortality. Conclusions Diaphragmatic stripping leads to a significantly lower rate of postoperative pulmonary and severe complications compared to diaphragmatic full-thickness resection, while oncological outcomes do not appear to be worse. Larger trials with standardized study protocols and long-term survival data are needed to validate the results presented here. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Stylianidi, M. C., Vaghiri, S., Pandkhahi, A., Kazziha, S., Al Akeel, W., Knoefel, W. T., & Prassas, D. (2025). Diaphragmatic stripping versus full-thickness diaphragmatic resection in cytoreductive surgery: a meta-analysis of the current evidence. Langenbeck’s Archives of Surgery, 410, Article 50. https://doi.org/10.1007/s00423-025-03611-0 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.04.2025 | |||||||
| Dateien geändert am: | 10.04.2025 |
