Dokument: Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham-controlled pilot trial
| Titel: | Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham-controlled pilot trial | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69290 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250410-120340-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Kujovic, Milenko [Autor] Bahr, Christian [Autor] Riesbeck, Mathias [Autor] Benz, Daniel [Autor] Deiß, Martina [Autor] Margittai, Zsofia [Autor] Henges, Sebastian [Autor] Reinermann, Dirk [Autor] Plewnia, Christian [Autor] Meisenzahl, Eva [Autor] | |||||||
| Dateien: |
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| Stichwörter: | iTBS, rTMS, DBT, Delay discounting, Impulsivity, Decision-making | |||||||
| Beschreibung: | Background
Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in treating borderline personality disorder (BPD). Impulsivity and impaired decision-making are prominent features of BPD, and therapeutic interventions targeting these symptoms could lead to significant improvements. Objective/Hypothesis We hypothesized that intermittent theta burst stimulation (iTBS), a modified rTMS protocol that targets the left dorsolateral prefrontal cortex, would enhance the therapeutic effects of DBT, leading to greater improvements in impulsivity and decision-making compared with sham stimulation. Methods We performed a single-blind, randomized, sham-controlled pilot study to evaluate the efficacy of iTBS as an add-on to an 8-week DBT program for BPD in a routine inpatient setting. A total of 53 BPD patients were randomly assigned to receive either iTBS (n = 25) or sham stimulation (n = 28) during weeks 4 to 8 of DBT, and 36 patients met the inclusion criteria for the present analysis (≥ 16 of 20 iTBS/sham sessions and assessment of delay discounting). The study endpoints were the Barratt Impulsiveness Scale-15 for impulsivity and the Monetary Choice Questionnaire for decision-making/delay discounting. Results A mixed model repeated measures analysis with a 2 × 2 factorial between-subjects design showed a significant overall improvement over time in impulsivity but not in decision-making/delay discounting. No significant differences were found between iTBS and sham, although post hoc tests revealed significant changes in impulsivity in the iTBS group (meandiff = -4.7, p = .001, Cohen’s d = 0.68) but not in the sham group (meandiff = -2.1, p = .077, d = 0.31). Conclusions iTBS may offer long-term benefits as an add-on treatment to DBT for impulsivity in BPD, suggesting the need for further investigation in larger-scale studies. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Kujovic, M., Bahr, C., Riesbeck, M., Benz, D., Deiß, M., Margittai, Z., Henges, S., Reinermann, D., Plewnia, C., & Meisenzahl-Lechner, E. (2025). Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham-controlled pilot trial. Borderline Personality Disorder and Emotion Dysregulation, 12, Article 2. https://doi.org/10.1186/s40479-025-00278-3 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.04.2025 | |||||||
| Dateien geändert am: | 10.04.2025 |
