Dokument: Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer
| Titel: | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69289 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250410-115053-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Valentin, Birte [Autor] Schimmöller. Lars [Autor] Boschheidgen, Matthias [Autor] Ullrich, Tim [Autor] Thiel, Thomas Andreas [Autor] Lijmani, Alexandra [Autor] Radtke, Jan Philipp [Autor] Benkert, Thomas [Autor] Albers, Peter [Autor] Antoch, Gerald [Autor] | |||||||
| Dateien: |
| |||||||
| Beschreibung: | Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. DWI post-processing was performed on 30 patients (median age 67 years, prostate specific antigen 8.0 ng/ml) with PC and clear MRI findings (PI-RADS 4 and 5). Multiparametric MRI was performed at 3 Tesla. A multi-shot readout segmentation (rs-EPI) plus zoomed single-shot imaging (z-EPI) sequence was used in 15 patients (group 1) and a single-shot echo-planar imaging (ss-EPI) plus rs-EPI sequence in 15 patients (group 2). B-value images (b1000 and b1800/2000) were squared and then evaluated objectively software-based and subjectively using a 5-point. The squared DWI technique showed a significantly higher contrast ratio (CR) for ss-EPI b1800 (p < 0.001), rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001), z-EPI b1000 (p = 0.008) and for z-EPI b2000 (p < 0.001). After post-processing, a significant improvement in the subjective assessment of image quality was observed for rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001) and z-EPI b1000 (p < 0.001). The application of the square post-processing to DWI results in a significant improvement in the CR between PC and healthy tissue, especially at high b-values of ss-EPI or re-EPI. This method may help to improve the detection and differentiation of PC lesions. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Valentin, B., Schimmöller, L., Boschheidgen, M., Ullrich, T., Thiel, T., Ljimani, A., Radtke, J. P., Benkert, T., Albers, P., Antoch, G., Wittsack, H.-J., & Quentin, M. (2025). Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer. Scientific Reports, 15, Article 3451. https://doi.org/10.1038/s41598-025-86068-x | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.04.2025 | |||||||
| Dateien geändert am: | 10.04.2025 |
