Dokument: Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis
| Titel: | Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69204 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250401-104629-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Räuber, Saskia [Autor] Schulte-Mecklenbeck, Andreas [Autor] Sarink, Kelvin [Autor] Golombeck, Kristin S. [Autor] Schroeter, Christina B. [Autor] Willison, Alice Grizzel [Autor] Nelke, Christopher [Autor] Strippel, Christine [Autor] Dik, Andre [Autor] Gallus, Marco [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Multidimensional flow cytometry, Herpes virus infections, Immune cells, Differential diagnoses, Autoimmune encephalitis | |||||||
| Beschreibung: | Background
Autoimmune encephalitis (AIE) is a disabling inflammatory condition of the brain deemed to be due to a dysregulated immune response. Viral infections and malignancies together with certain genetic polymorphisms are thought to contribute to the pathogenesis of AIE, yet the exact mechanisms remain insufficiently understood. Diagnosis of AIE currently relies on clinical consensus criteria. However, diagnostic workup can be challenging in some cases, potentially delaying treatment initiation associated with poor clinical outcomes. This study aims to investigate the systemic and intrathecal immune cell profiles of AIE in comparison to viral meningoencephalitis (VME) as a clinically relevant differential diagnosis and evaluate its diagnostic and therapeutic potential. Methods 97 mainly treatment-naïve AIE patients, 47 patients with VME, and 109 somatic symptom disorder (SD) controls were included. Analysis of peripheral blood (PB) and cerebrospinal fluid (CSF) immune cell profiles was performed using multidimensional flow cytometry (mFC) in combination with novel computational approaches. Results We were able to identify alterations in the adaptive B and T cell-mediated immune response in AIE compared to SD controls which correspond to respective changes in the brain parenchyma. AIE and VME exhibit similar patterns of adaptive B and T cell responses and differ in pattern of innate immunity especially NK cells. MFC together with routine CSF parameters can differentiate AIE from VME and SD controls implying diagnostic potential. Conclusion AIE is characterized by a B and T cell-mediated systemic and intrathecal immune-cell signature which corresponds to changes reported in the brain parenchyma providing insights into immunopathogenesis. Differences between AIE and VME were most prominent for the innate immune response indicating a potential role of NK cells in the pathogenesis of autoimmunity. Our data provides evidence that mFC could be a novel complementary approach to the diagnosis of AIE with diagnostic, therapeutic, and prognostic implications. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Räuber, S., Schulte-Mecklenbeck, A., Sarink, K., Golombeck, K. S., Menskes, C. B., Willison, A. G., Nelke, C., Strippel, C., Dik, A., Gallus, M., Kovac, S., Wiendl, H., Meyer zu Hörste, G., Ruck, T., Grauer, O. M., Dannlowski, U., Hahn, T., Gross, C. C., Meuth, S., & Melzer, N. (2025). Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis. Journal of Autoimmunity, 152, Article 103396. https://doi.org/10.1016/j.jaut.2025.103396 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 01.04.2025 | |||||||
| Dateien geändert am: | 01.04.2025 |
