Dokument: MRI characteristics predict risk of pathological upgrade in patients with ISUP grade group 1 prostate cancer
| Titel: | MRI characteristics predict risk of pathological upgrade in patients with ISUP grade group 1 prostate cancer | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69183 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250331-093939-2 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Boschheidgen, Matthias [Autor] Schimmöller. Lars [Autor] Radtke, Jan Philipp [Autor] Kastl, Rebecca [Autor] Jannusch, Kai [Autor] Lakes, Jale [Autor] Drewes, Lukas [Autor] Radke, Karl Ludger [Autor] Esposito, Irene [Autor] Albers, Peter [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | Low-risk prostate cancer, Multiparametric magnetic resonance imaging, Risk stratification, Prostatic neoplasms | |||||||
| Beschreibung: | Objective
This study aims to analyse multiparametric MRI (mpMRI) characteristics of patients diagnosed with ISUP grade group (GG) 1 prostate cancer (PC) on initial target plus systematic MRI/TRUS fusion-guided biopsy and investigate histopathological progression during follow-up. Methods A retrospective single-centre cohort analysis was conducted on consecutive patients with mpMRI visible lesions (PI-RADS ≥ 3) and detection of ISUP-1-PC at the time of initial biopsy. The study assessed clinical, mpMRI, and histopathological parameters. Subcohorts were analysed with (1) patients who had confirmed ISUP-1-PC and (2) patients who experienced histopathological upgrading to ISUP ≥ 2 PC during follow-up either at re-biopsy or radical prostatectomy (RP). Results A total of 156 patients (median age 65 years) between March 2014 and August 2021 were included. Histopathological upgrading to ISUP ≥ 2 was detected in 55% of patients during a median follow-up of 9.5 months (IQR 2.2–16.4). When comparing subgroups with an ISUP upgrade and sustained ISUP 1 PC, they differed significantly in contact length of the index lesion to the pseudocapsule, ADC value, PI-RADS category, and the MRI grading group (mGG) (p < 0.05). In the ISUP GG ≥ 2 subgroup, 91% of men had PI-RADS category 4 or 5 and 82% exhibited the highest mGG (mGG3). In multivariate analysis, mGG was the only independent parameter for predicting ISUP ≥ 2-PC in these patients. Conclusions MRI reveals important information about PC aggressiveness and should be incorporated into clinical decision-making when ISUP-1-PC is diagnosed. In cases of specific MRI characteristics adverse to the histopathology, early re-biopsy might be considered. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Boschheidgen, M., Schimmöller, L., Radtke, J. P., Kastl, R., Jannusch, K., Lakes, J., Drewes, L., Radke, K. L., Esposito, I., Albers, P., Antoch, G., Ullrich, T., & Al-Monajjed, R. (2024). MRI characteristics predict risk of pathological upgrade in patients with ISUP grade group 1 prostate cancer. European Radiology, 35(4), 2170–2179. https://doi.org/10.1007/s00330-024-11062-2 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 31.03.2025 | |||||||
| Dateien geändert am: | 31.03.2025 |
