Dokument: The N terminus-only function of adhesion GPCRs: emerging concepts
| Titel: | The N terminus-only function of adhesion GPCRs: emerging concepts | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=69181 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250331-091934-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Lehmann, Laura [Autor] Groß, Victoria Elisabeth [Autor] Behlendorf, Rene [Autor] Prömel, Simone [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | signaling, trans, 7TM-independent, N terminus-only, bidirectional signals, adhesion GPCRs | |||||||
| Beschreibung: | Adhesion G-protein-coupled receptors (aGPCRs) play key roles in health and disease. They are unique in that they not only activate G-protein pathways but also have distinct functions that rely solely on their N termini, making them complex drug targets. To date there have been only descriptive observations about these enigmatic N terminus-only functions. Emerging evidence from several aGPCRs now indicates that these are a defining characteristic of these receptors that allows them to operate bidirectionally across environments. Recent advances in characterizing aGPCR splice variants and receptor structure have revealed the G protein-independent mechanisms that underlie their N terminus-only functions. This review consolidates current findings, explores how the N termini integrate functions, and identifies common principles across aGPCRs. We consider the therapeutic implications and discuss how specifically targeting N terminus functions provides a novel perspective on the pharmacological potential of aGPCRs. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Lehmann, L., Groß, V. E., Behlendorf, R., & Prömel, S. (2025). The N terminus-only function of adhesion GPCRs: emerging concepts. Trends in Pharmacological Sciences, 46(3), 231–248. https://doi.org/10.1016/j.tips.2025.01.004 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 31.03.2025 | |||||||
| Dateien geändert am: | 31.03.2025 |
