Dokument: Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis
| Titel: | Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68987 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250311-120735-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Mori, Yuriko [Autor] Kramer, Vasko [Autor] Novruzov, Emil [Autor] Mamlins, Eduards [Autor] Röhrich, Manuel [Autor] Fernández, René [Autor] Soza-Ried, Cristian [Autor] Amaral, Horacio [Autor] Monje, Barbara [Autor] Sabbagh, Eduardo [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Fibrosis, Fibroblast activation protein, FAPI, Idiopathic pulmonary disease, PET | |||||||
| Beschreibung: | Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis. 68Ga-labeled FAP ligands exhibited highly promising results due to the crucial role of activated fibroblasts in fibrosis imaging of the lung. However, 18F-labeled FAP ligands might provide qualitatively much higher imaging results with accompanying economic benefits due to large-scale production. Thus, we sought to investigate the potential of [18F]FAPI-74 prospectively in a small patient cohort. Methods Eight patients underwent both [18F]FAPI-74-PET/CT and HRCT scans and were then compared with a control group without any fibrosing pulmonary disease. The tracer uptake of fibrotic lung areas was analyzed in synopsis with radiological and clinical parameters. Results We observed a positive correlation between the fibrotic active volume, the Hounsfield scale, as well as the vital and diffusing capacity of the lung. Conclusion The initial results confirm our assumption that [18F]FAPI-74 offers a viable non-invasive assessment method for pulmonary fibrotic changes in patients with IPF. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Mori, Y., Kramer, V., Novruzov, E., Mamlins, E., Röhrich, M., Fernández, R., Amaral, H., Soza-Ried, C., Monje, B., Sabbagh, E., Florenzano, M., Giesel, F. L., & Undurraga, Á. (2023). Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis. European Journal of Nuclear Medicine & Molecular Imaging, 51(6), 1605–1611. https://doi.org/10.1007/s00259-023-06564-y | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 11.03.2025 | |||||||
| Dateien geändert am: | 11.03.2025 |
