Dokument: MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer
| Titel: | MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68867 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250228-120745-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Boschheidgen, Matthias [Autor] Schimmöller. Lars [Autor] Kastl, Rebecca [Autor] Drewes, Lukas [Autor] Jannusch, Kai [Autor] Radke, Karl Ludger [Autor] Kirchner, Julian [Autor] Ullrich, Tim [Autor] Niegisch, Günter [Autor] Albers, Peter [Autor] | |||||||
| Dateien: |
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| Stichwörter: | High-risk prostate cancer, Risk stratification, Multiparametric magnetic resonance imaging, Prostatic neoplasms | |||||||
| Beschreibung: | Objectives
To analyze multiparametric MRI (mpMRI) characteristics of patients with International Society of Urological Pathology (ISUP) grade group (GG) 4 or 5 prostate cancer (PC) and to correlate MRI parameters with the occurrence of biochemical recurrence (BCR) after radical prostatectomy (RPE). Methods In this single-center cohort study consecutive patients with mpMRI and ISUP GG 4 or 5 PC were retrospectively analyzed. Clinical, MR-guided biopsy, and diagnostic mpMRI parameter were assessed. A subcohort of patients with RPE and follow-up was analyzed separately. A univariate and multivariate analyses were performed to determine parameters that are associated to patients with BCR after RPE. Results 145 patients (mean age 70y, median PSA 10.9 ng/ml) were analyzed. 99% had a PI-RADS classification of 4 or 5, 48% revealed MRI T3 stage, and median diameter of the MRI index lesion (IL) was 15 mm. IL showed a median ADC value of 668 ×10−6 mm2/s and exhibited contrast enhancement in 94% of the cases. For patients with follow-up after RPE (n = 82; mean follow-up time 68 ± 27 m), MRI parameters were significantly different for contact length of the IL to the pseudocapsule (LCC), MRI T3 stage, and IL localization (p < 0.05). Higher PSAD and MRI T3 stage were independent parameters for the risk of BCR when incorporating clinical, biopsy, and MRI parameters. Conclusion ISUP GG 4 or 5 PC has distinctive characteristics on mpMRI and were detected on MRI in all cases. In addition, higher PSAD and MRI T3 stage were significant predictors for BCR after RPE. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Boschheidgen, M., Schimmöller, L., Kastl, R., Drewes, L., Jannusch, K., Radke, K. L., Kirchner, J. P., Ullrich, T., Niegisch, G., Albers, P., Antoch, G., & Radtke, J. P. (2023). MRI characteristics and oncological follow-up of patients with ISUP grade group 4 or 5 prostate cancer. Abdominal Radiology, 49, 192–201. https://doi.org/10.1007/s00261-023-04073-y | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 28.02.2025 | |||||||
| Dateien geändert am: | 28.02.2025 |
