Dokument: Herpes zoster is not associated with subsequent gastrointestinal cancer: data from over 200,000 outpatients in Germany
| Titel: | Herpes zoster is not associated with subsequent gastrointestinal cancer: data from over 200,000 outpatients in Germany | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68842 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250227-120227-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Leyh, Catherine [Autor] Roderburg, Christoph [Autor] Luedde, Tom [Autor] Loosen, Sven H. [Autor] Kostev, Karel [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Varicella zoster virus, Epidemiology, Herpes zoster, Malignancy, Gastrointestinal cancer | |||||||
| Beschreibung: | Purpose
Gastrointestinal (GI) cancers are an increasing global health challenge. Viral diseases play an important role in the development of GI cancers. For example, Epstein-Barr virus, which belongs to the human herpesvirus family, is a well-recognized risk factor for the development of gastric cancer. The purpose of this study was to investigate a possible association between varicella-zoster virus reactivation and subsequent diagnosis of GI cancer. Methods In this retrospective cohort study, a total of 103,123 patients with a first diagnosis of herpes zoster (HZ) between 2005 and 2021 were propensity score matched to a cohort of 103,123 patients without HZ. Patient data was extracted from the Disease Analyzer database (IQVIA). The incidence of GI cancer was compared as a function of HZ. Cox regression analysis was used to examine the association between HZ and GI cancer. Results Over a follow-up period of up to 10 years, the incidence of GI cancer did not differ between the two cohorts (HZ cohort 2.26 cases per 1000 patient-years vs. non-HZ cohort 2.37 cases per 1000 patient-years, p = 0.548). In regression analysis, HZ was not associated with an increased risk of developing GI cancer (HR: 0.97; 95% CI 0.89–1.05). Furthermore, no significant effect of the presence of HZ on the incidence of different GI cancer entities was found. Conclusion In this retrospective cohort study consisting of well-matched patients, we observed no significant association between a HZ infection and the development of GI cancer during a long-term follow-up. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Leyh, C., Roderburg, C., Lüdde, T., Loosen, S. H., & Kostev, K. (2023). Herpes zoster is not associated with subsequent gastrointestinal cancer: data from over 200,000 outpatients in Germany. Journal of Cancer Research and Clinical Oncology, 149(19), 17115–17121. https://doi.org/10.1007/s00432-023-05432-4 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 27.02.2025 | |||||||
| Dateien geändert am: | 27.02.2025 |
