Dokument: Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
| Titel: | Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68707 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250219-133413-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Gallus, Marco [Autor] Roll, Wolfgang [Autor] Dik, Andre [Autor] Barca, Cristina [Autor] Zinnhardt, Bastian [Autor] Hicking, Gordon [Autor] Mueller, Christoph [Autor] Narayanan Naik, Venu [Autor] Anstötz, Max [Autor] Krämer, Julia [Autor] | |||||||
| Dateien: |
| |||||||
| Beschreibung: | Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed.
Here, we demonstrate that visualization of the translocator protein (TSPO) with [18F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell–mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [18 F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell–mediated ALE. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Gallus, M., Roll, W., Dik, A., Barca, C., Zinnhardt, B., Hicking, G., Mueller, C., Naik, V. N., Anstötz, M., Krämer, J., Rolfes, L., Wachsmuth, L., Pitsch, J., van Loo, K. M. J., Räuber, S., Okada, H., Wimberley, C., Strippel, C., Golombeck, K. S., … Melzer, N. (2023). Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis. Science Advances, 9(23), Article eabq7595. https://doi.org/10.1126/sciadv.abq7595 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 19.02.2025 | |||||||
| Dateien geändert am: | 19.02.2025 |
