Dokument: Determinants of patient and physician global assessments of disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis
| Titel: | Determinants of patient and physician global assessments of disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68691 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250218-120320-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Rohde, Marius [Autor] Kernder, Anna [Autor] Acar, Hasan [Autor] Düsing, Christina [Autor] Fischer-Betz, Rebecca [Autor] Haase, Isabell [Autor] Mucke, Johanna [Autor] Sander, Oliver [Autor] Richter, Jutta G. [Autor] Filla, Tim [Autor] | |||||||
| Dateien: |
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| Stichwörter: | disease activity, global disease assessment, patient-reported outcome, pain, ANCA associated vasculitis | |||||||
| Beschreibung: | Objective: To compare physician and patient assessments of global disease activity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and to identify associated factors.
Methods: Global disease activity scores (0–10 points) were retrospectively analyzed from physicians and patients with AAV at each outpatient visit from 2010 to 2020. We compared the scores and performed a linear regression with a random effects to identify associated factors. Results: Patients (n = 143, 1,291 pairs, 52% female) had a mean 64 (±15) years of age and a mean disease duration of 9 (±7) years. Patients and physicians global disease activity assessments showed a moderate correlation (Pearson R 0.31, CI [0.23–0.52], p < 0.001). Linear regression showed a strong association between the physician-documented disease activity scores and serum CRP levels (β = 0.22, CI [0.18, 0.28]), disease duration (β = −0.022, CI [−0.04,-0.01]) and patients’ assessment of disease activity (β = 0.08, CI [0.04, 0.12]). By contrast, patient assessments were strongly associated with the degree of pain (β = 0.30, CI [0.25, 0.35]), functional limitations in daily living (HAQ, β = 0.49, CI [0.21, 0.78]) and the global physical well-being (NRS, β = 0.39, CI [0.32, 0.46]). Conclusion: Patients’ and physicians’ assessments of disease activity correlated. High CRP levels and disease duration were associated with physician-assessed disease activity scores, while subjective limitations were associated with higher patient-assessed disease activity scores. These findings highlight and support the need to develop and evaluate patient-reported outcomes to assess disease activity in patients diagnosed with AAV. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Rohde, M., Kernder, A. L., Acar, H., Düsing, C., Fischer-Betz, R., Haase, I., Mucke, J., Sander, O., Richter, J., Filla, T., Schneider, M., & Chehab, G. (2023). Determinants of patient and physician global assessments of disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis. Frontiers in Medicine, 10, Article 1052729. https://doi.org/10.3389/fmed.2023.1107148 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.02.2025 | |||||||
| Dateien geändert am: | 18.02.2025 |
