Dokument: Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
| Titel: | Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68689 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250218-113900-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Jannusch, Kai [Autor] Bittner, Ann-Kathrin [Autor] Bruckmann, Nils-Martin [Autor] Morawitz, Janna [Autor] Stieglitz, Cleo [Autor] Dietzel, Frederic [Autor] Quick, Harald H. [Autor] Baba, Hideo A. [Autor] Herrmann, Ken [Autor] Umutlu, Lale [Autor] | |||||||
| Dateien: |
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| Stichwörter: | PET/MRI, breast cancer, imaging biopsy, DTC | |||||||
| Beschreibung: | Purpose: Evaluate the diagnostic potential of [18F]FDG-PET/MRI data compared with invasive acquired biomarkers in newly diagnosed early breast cancer (BC). Methods: Altogether 169 women with newly diagnosed BC were included. All underwent a breast- and whole-body [18F]FDG-PET/MRI for initial staging. A tumor-adapted volume of interest was placed in the primaries and defined bone regions on each standard uptake value (SUV)/apparent diffusion coefficient (ADC) dataset. Immunohistochemical markers, molecular subtype, tumor grading, and disseminated tumor cells (DTCs) of each patient were assessed after ultrasound-guided biopsy of the primaries and bone marrow (BM) aspiration. Correlation analysis and group comparisons were assessed. Results: A significant inverse correlation of estrogen-receptor (ER) expression and progesterone-receptor (PR) expression towards SUVmax was found (ER: r = 0.27, p < 0.01; PR: r = 0.19, p < 0.05). HER2-receptor expression showed no significant correlation towards SUV and ADC values. A significant positive correlation between Ki67 and SUVmax and SUVmean (r = 0.42 p < 0.01; r = 0.19 p < 0.05) was shown. Tumor grading significantly correlated with SUVmax and SUVmean (ρ = 0.36 and ρ = 0.39, both p’s < 0.01). There were no group differences between SUV/ADC values of DTC-positive/-negative patients. Conclusions: [18F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Jannusch, K., Bittner, A.-K., Bruckmann, N.-M., Morawitz, J., Stieglitz, C., Dietzel, F., Quick, H. H., Baba, H. A., Herrmann, K., Umutlu, L., Antoch, G., Kirchner, J. P., Kasimir-Bauer, S., & Hoffmann, O. (2023). Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer. Cancers, 15(6), Article 1651. https://doi.org/10.3390/cancers15061651 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.02.2025 | |||||||
| Dateien geändert am: | 18.02.2025 |
