Dokument: The N terminus-only (trans) function of the adhesion G protein-coupled receptor latrophilin-1 controls multiple processes in reproduction of Caenorhabditis elegans
| Titel: | The N terminus-only (trans) function of the adhesion G protein-coupled receptor latrophilin-1 controls multiple processes in reproduction of Caenorhabditis elegans | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68497 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250207-140440-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Matúš, Daniel [Autor] Post, Willem Berend [Autor] Groß, Victoria Elisabeth [Autor] Knierim, Alexander Bernd [Autor] Kuhn, Christina Katharina [Autor] Fiedler, Franziska [Autor] Tietgen, Darian Benno [Autor] Schön, Johanna Lena [Autor] Schöneberg, Torsten [Autor] Prömel, Simone [Autor] | |||||||
| Dateien: |
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| Stichwörter: | apoptosis, sperm guidance, ovulation, latrophilin, adhesion GPCR, germ cells, trans function | |||||||
| Beschreibung: | Adhesion G protein-coupled receptors are unique molecules. They are able to transmit classical signals via G protein activation as well as mediate functions solely through their extracellular N termini, completely independently of the seven transmembrane helices domain and the C terminus. This dual mode of action is highly unusual for G protein-coupled receptors and allows for a plethora of possible cellular consequences. However, the physiological implications and molecular details of this N terminus-mediated signaling are poorly understood. Here, we show that several distinct seven transmembrane helices domain-independent/trans functions of the adhesion G protein-coupled receptor latrophilin homolog latrophilin-1 in the nematode Caenorhabditis elegans together regulate reproduction: sperm guidance, ovulation, and germ cell apoptosis. In these contexts, the receptor elicits its functions in a noncell autonomous manner. The functions might be realized through alternative splicing of the receptor specifically generating N terminus-only variants. Thus, our findings shed light on the versatility of seven transmembrane helices domain-independent/N terminus-only/trans functions of adhesion G protein-coupled receptor and discuss possible molecular details. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Matúš, D., Post, W. B., Groß, V. E., Knierim, A. B., Kuhn, C. K., Fiedler, F., Tietgen, D. B., Schön, J. L., Schöneberg, T., & Prömel, S. (2024). The N terminus-only (trans) function of the adhesion G protein-coupled receptor latrophilin-1 controls multiple processes in reproduction of Caenorhabditis elegans. G3: Genes, Genomes, Genetics, 14(11), Article jkae206. https://doi.org/10.1093/g3journal/jkae206 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 07.02.2025 | |||||||
| Dateien geändert am: | 07.02.2025 |
