Dokument: Nucleophosmin: A Nucleolar Phosphoprotein Orchestrating Cellular Stress Responses
| Titel: | Nucleophosmin: A Nucleolar Phosphoprotein Orchestrating Cellular Stress Responses | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68494 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250207-132158-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Taha, Mohamed S. [Autor] Ahmadian, Mohammad Reza [Autor] | |||||||
| Dateien: |
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| Stichwörter: | molecular chaperone, nucleoplasmin, DNA repair, nucleocytoplasmic shuttling, nucleophosmin, stress response, apoptosis, NPM1, nucleolar phosphoprotein | |||||||
| Beschreibung: | Nucleophosmin (NPM1) is a key nucleolar protein released from the nucleolus in response to stress stimuli. NPM1 functions as a stress regulator with nucleic acid and protein chaperone activities, rapidly shuttling between the nucleus and cytoplasm. NPM1 is ubiquitously expressed in tissues and can be found in the nucleolus, nucleoplasm, cytoplasm, and extracellular environment. It plays a central role in various biological processes such as ribosome biogenesis, cell cycle regulation, cell proliferation, DNA damage repair, and apoptosis. In addition, it is highly expressed in cancer cells and solid tumors, and its mutation is a major cause of acute myeloid leukemia (AML). This review focuses on NPM1’s structural features, functional diversity, subcellular distribution, and role in stress modulation. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Taha, M. S. A., & Ahmadian, M. R. (2024). Nucleophosmin: A Nucleolar Phosphoprotein Orchestrating Cellular Stress Responses. Cells, 13(15), Article 1266. https://doi.org/10.3390/cells13151266 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 07.02.2025 | |||||||
| Dateien geändert am: | 07.02.2025 |
