Dokument: Effects of Local Vasodilators and the Autonomic Nervous System on Microcirculation and Mitochondrial Function in Septic Rats
| Titel: | Effects of Local Vasodilators and the Autonomic Nervous System on Microcirculation and Mitochondrial Function in Septic Rats | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68470 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250206-115724-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Marcus, Carsten [Autor] Hansen, Claudia [Autor] Schlimgen, Charlotte [Autor] Eitner-Pchalek, Jeanne [Autor] Schulz, Jan [Autor] Hof, Stefan [Autor] Kuebart, Anne [Autor] Truse, Richard [Autor] Vollmer, Christian [Autor] Bauer, Inge [Autor] | |||||||
| Dateien: |
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| Stichwörter: | animal model, CASP, iloprost, microcirculation, carbachol, vasodilators, nitroglycerin, sepsis, mitochondria | |||||||
| Beschreibung: | Systemic vasodilating agents like nitroglycerin (NG) or iloprost (Ilo) show beneficial effects on intestinal microcirculation during sepsis, which could be attenuated by activation of the sympathetic nervous system or systemic side effects of vasodilating agents. This exploratory study aimed to investigate the effects of topically administered vasodilators and the parasympathetic drug carbachol on colonic microcirculatory oxygenation (µHbO2), blood flow (µFlow) and mitochondrial respiration. A total of 120 male Wistar rats were randomly assigned to twelve groups and underwent either colon ascendens stent peritonitis (CASP) or sham surgery. After 24 h, animals received the following therapeutic regimes: (1) balanced full electrolyte solution, (2) carbachol, (3) NG, (4) Ilo, (5) NG + carbachol, and (6) Ilo + carbachol. Mitochondrial respiration was measured in colon homogenates by respirometry. In sham animals, NG (−13.1%*) and Ilo (−10.5%*) led to a decrease in µHbO2. Additional application of carbachol abolished this effect (NG + carbachol: −4.0%, non-significant; Ilo + carbachol: −1.4%, non-significant). In sepsis, carbachol reduced µHbO2 when applied alone (−10.5%*) or in combination with NG (−17.6%*). Thus, the direction and degree of this effect depend on the initial pathophysiologic condition. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Marcus, C., Hansen, C., Schlimgen, C., Eitner-Pchalek, J., Schulz, J. W., Hof, S., Kuebart, A., Truse, R., Vollmer, C., Bauer, I., Picker, O., & Herminghaus, A. (2024). Effects of Local Vasodilators and the Autonomic Nervous System on Microcirculation and Mitochondrial Function in Septic Rats. International Journal of Molecular Sciences, 25(17), Article 9305. https://doi.org/10.3390/ijms25179305 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 06.02.2025 | |||||||
| Dateien geändert am: | 06.02.2025 |
