Dokument: Platelets Induce Cell Apoptosis of Cardiac Cells via FasL after Acute Myocardial Infarction
| Titel: | Platelets Induce Cell Apoptosis of Cardiac Cells via FasL after Acute Myocardial Infarction | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68455 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250205-135848-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Krott, Kim Jürgen [Autor] Reusswig, Friedrich [Autor] Dille, Matthias [Autor] Krüger, Evelyn [Autor] Gorressen, Simone [Autor] Karray, Saoussen [Autor] Polzin, Amin [Autor] Kelm, Malte [Autor] Fischer, Jens W. [Autor] Elvers, Margitta [Autor] | |||||||
| Dateien: |
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| Stichwörter: | myocardial infarction, Fas ligand, platelets, apoptosis, cardiomyocytes | |||||||
| Beschreibung: | Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Cell apoptosis in the myocardium plays an important role in ischemia and reperfusion (I/R) injury, leading to cardiac damage and dysfunction. Platelets are major players in hemostasis and play a crucial role in vessel occlusion, inflammation, and cardiac remodeling after I/R. Here, we studied the impact of platelets on cell apoptosis in the myocardium using a close-chest mouse model of AMI. We found caspase-3-positive resident cardiac cells, while leukocytes were negative for caspase-3. Using two different mouse models of thrombocytopenia, we detected a significant reduction in caspase-3 positive cells in the infarct border zone after I/R injury. Further, we identified platelet FasL to induce cell apoptosis via the extrinsic pathway of Fas receptor activation of target cells. Mechanistically, hypoxia triggers platelet adhesion to FasR, suggesting that platelet-induced apoptosis is elevated after I/R. Platelet-specific FasL knock-out mice showed reduced Bax and Bcl2 expression, suggesting that platelets modulate the intrinsic and extrinsic pathways of apoptosis, leading to reduced infarct size after myocardial I/R injury. Thus, a new mechanism for how platelets contribute to tissue homeostasis after AMI was identified that should be validated in patients soon. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Krott, K. J., Reusswig, F., Dille, M., Krüger, E., Gorreßen, S., Karray, S., Polzin, A., Kelm, M., Fischer, J. W., & Elvers, M. (2024). Platelets Induce Cell Apoptosis of Cardiac Cells via FasL after Acute Myocardial Infarction. Biomedicines, 12(5), Article 1077. https://doi.org/10.3390/biomedicines12051077 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 05.02.2025 | |||||||
| Dateien geändert am: | 05.02.2025 |
